TY - GEN
T1 - Study on Network Pharmacology of Jiuwei Zhenxin Granules in the Treatment of Bipolar Disorder
AU - Ma, Enlian
AU - Xie, Yingying
AU - Chen, Haoxi
AU - He, Liyu
AU - Liang, Yufen
AU - Wang, Ying
AU - Liu, Xiaogang
N1 - Publisher Copyright:
© 2024 Copyright held by the owner/author(s).
PY - 2024/12/2
Y1 - 2024/12/2
N2 - In this study, we inquired about the composition and efficacy of Jiuwei Zhenxin Granules, searched for relevant information using databases, obtained the action targets through TCMSP database and scored them, screened the bipolar disorder related targets in OMIM database, and finally constructed the target network by using String and Cytoscape, imported into Metascape, performed the KEGG analysis and visualization. The results showed that the key genes of bipolar disorder were CSRNP3, PIK3R1, RNF115, NRIP3, KIF3A, DYNC1LI1, PCMT1, CHL1, SLC25A32, SEH1L, COPS4, ARVCF, EPN1, RTEL1, PTOV1-AS2, GUCA2A, EPHB4. We also mined each active ingredient of Jiuwei Zhenxin Granule and constructed a network for further enrichment and elaboration, and obtained the key targets CASP3, PTGS2, PPARG, NOS3, and the key pharmacological active ingredient J1 (Stigmasterol), J6 (Quercetin) explaining the molecular mechanism of Jiuwei Zhenxin Granule in the treatment of bipolar affective disorders.
AB - In this study, we inquired about the composition and efficacy of Jiuwei Zhenxin Granules, searched for relevant information using databases, obtained the action targets through TCMSP database and scored them, screened the bipolar disorder related targets in OMIM database, and finally constructed the target network by using String and Cytoscape, imported into Metascape, performed the KEGG analysis and visualization. The results showed that the key genes of bipolar disorder were CSRNP3, PIK3R1, RNF115, NRIP3, KIF3A, DYNC1LI1, PCMT1, CHL1, SLC25A32, SEH1L, COPS4, ARVCF, EPN1, RTEL1, PTOV1-AS2, GUCA2A, EPHB4. We also mined each active ingredient of Jiuwei Zhenxin Granule and constructed a network for further enrichment and elaboration, and obtained the key targets CASP3, PTGS2, PPARG, NOS3, and the key pharmacological active ingredient J1 (Stigmasterol), J6 (Quercetin) explaining the molecular mechanism of Jiuwei Zhenxin Granule in the treatment of bipolar affective disorders.
KW - Bioinformatics
KW - Bipolar disorder
KW - Jiuwei Zhenxin Granules
KW - Network pharmacology
KW - Signaling pathways
UR - https://www.scopus.com/pages/publications/85216097351
U2 - 10.1145/3700486.3700503
DO - 10.1145/3700486.3700503
M3 - Conference contribution
AN - SCOPUS:85216097351
T3 - ACM International Conference Proceeding Series
SP - 103
EP - 110
BT - Proceedings of 2024 International Conference on Biomedicine and Intelligent Technology, ICBIT 2024
PB - Association for Computing Machinery
T2 - 2024 International Conference on Biomedicine and Intelligent Technology, ICBIT 2024
Y2 - 23 August 2024 through 25 August 2024
ER -