Strategies to construct efficient singlet oxygen-generating photosensitizers

E. Pang; Shaojing Zhao; Benhua Wang; Guangle Niu; Xiangzhi Song; Minhuan Lan

doi:10.1016/j.ccr.2022.214780

Strategies to construct efficient singlet oxygen-generating photosensitizers

E. Pang
, Shaojing Zhao
, Benhua Wang
, Guangle Niu^*
, Xiangzhi Song
, Minhuan Lan

^*Corresponding author for this work

College of Chemistry and Chemical Engineering
Shandong University

Research output: Contribution to journal › Review article › peer-review

95 Citations (Scopus)

Abstract

Singlet oxygen (¹O₂) generation is an essential function of photosensitizer (PS) as applied to photodynamic therapy (PDT) of cancer. As illustrated in the Jablonski diagram, the generation of ¹O₂ is directly related to the process of intersystem crossing (ISC), in which a high ISC efficiency typically correlates with a high quantum yield (QY) of ¹O₂. In recent years, multiple strategies have been adopted to improve ISC efficiency, including tuning chemical structures and reducing aggregation-caused quenching (ACQ), thus increase the ¹O₂ QY of PS. Here, we systematically summarize and compare the advantages and disadvantages of these strategies through analysis of some representative examples. In addition, we also discuss the challenges and obstacles encountered in the development of PS with high ¹O₂ generation efficiency and propose directions for future clinical applications of PDT.

Original language	English
Article number	214780
Journal	Coordination Chemistry Reviews
Volume	472
DOIs	https://doi.org/10.1016/j.ccr.2022.214780
Publication status	Published - 1 Dec 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aggregation-induced emission
Intersystem crossing
Photodynamic therapy
Photosensitizer
Singlet oxygen quantum yield

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10.1016/j.ccr.2022.214780

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title = "Strategies to construct efficient singlet oxygen-generating photosensitizers",

abstract = "Singlet oxygen (1O2) generation is an essential function of photosensitizer (PS) as applied to photodynamic therapy (PDT) of cancer. As illustrated in the Jablonski diagram, the generation of 1O2 is directly related to the process of intersystem crossing (ISC), in which a high ISC efficiency typically correlates with a high quantum yield (QY) of 1O2. In recent years, multiple strategies have been adopted to improve ISC efficiency, including tuning chemical structures and reducing aggregation-caused quenching (ACQ), thus increase the 1O2 QY of PS. Here, we systematically summarize and compare the advantages and disadvantages of these strategies through analysis of some representative examples. In addition, we also discuss the challenges and obstacles encountered in the development of PS with high 1O2 generation efficiency and propose directions for future clinical applications of PDT.",

keywords = "Aggregation-induced emission, Intersystem crossing, Photodynamic therapy, Photosensitizer, Singlet oxygen quantum yield",

author = "E. Pang and Shaojing Zhao and Benhua Wang and Guangle Niu and Xiangzhi Song and Minhuan Lan",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = dec,

day = "1",

doi = "10.1016/j.ccr.2022.214780",

language = "English",

volume = "472",

journal = "Coordination Chemistry Reviews",

issn = "0010-8545",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Strategies to construct efficient singlet oxygen-generating photosensitizers

AU - Pang, E.

AU - Zhao, Shaojing

AU - Wang, Benhua

AU - Niu, Guangle

AU - Song, Xiangzhi

AU - Lan, Minhuan

PY - 2022/12/1

Y1 - 2022/12/1

N2 - Singlet oxygen (1O2) generation is an essential function of photosensitizer (PS) as applied to photodynamic therapy (PDT) of cancer. As illustrated in the Jablonski diagram, the generation of 1O2 is directly related to the process of intersystem crossing (ISC), in which a high ISC efficiency typically correlates with a high quantum yield (QY) of 1O2. In recent years, multiple strategies have been adopted to improve ISC efficiency, including tuning chemical structures and reducing aggregation-caused quenching (ACQ), thus increase the 1O2 QY of PS. Here, we systematically summarize and compare the advantages and disadvantages of these strategies through analysis of some representative examples. In addition, we also discuss the challenges and obstacles encountered in the development of PS with high 1O2 generation efficiency and propose directions for future clinical applications of PDT.

AB - Singlet oxygen (1O2) generation is an essential function of photosensitizer (PS) as applied to photodynamic therapy (PDT) of cancer. As illustrated in the Jablonski diagram, the generation of 1O2 is directly related to the process of intersystem crossing (ISC), in which a high ISC efficiency typically correlates with a high quantum yield (QY) of 1O2. In recent years, multiple strategies have been adopted to improve ISC efficiency, including tuning chemical structures and reducing aggregation-caused quenching (ACQ), thus increase the 1O2 QY of PS. Here, we systematically summarize and compare the advantages and disadvantages of these strategies through analysis of some representative examples. In addition, we also discuss the challenges and obstacles encountered in the development of PS with high 1O2 generation efficiency and propose directions for future clinical applications of PDT.

KW - Aggregation-induced emission

KW - Intersystem crossing

KW - Photodynamic therapy

KW - Photosensitizer

KW - Singlet oxygen quantum yield

UR - https://www.scopus.com/pages/publications/85136470890

U2 - 10.1016/j.ccr.2022.214780

DO - 10.1016/j.ccr.2022.214780

M3 - Review article

AN - SCOPUS:85136470890

SN - 0010-8545

VL - 472

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

M1 - 214780

ER -

Strategies to construct efficient singlet oxygen-generating photosensitizers

Abstract

UN SDGs

Keywords

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