Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/ Michael addition via dynamic kinetic resolution: Access to highly functionalized chromans with three contiguous stereocenters

Wen Yang, Yi Yang, Da Ming Du*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)

Abstract

An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa- Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.

Original languageEnglish
Pages (from-to)1190-1193
Number of pages4
JournalOrganic Letters
Volume15
Issue number6
DOIs
Publication statusPublished - 15 Mar 2013

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