Abstract
An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa- Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.
Original language | English |
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Pages (from-to) | 1190-1193 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 15 |
Issue number | 6 |
DOIs | |
Publication status | Published - 15 Mar 2013 |