Spectroscopic-speckle variance OCT for microvasculature detection and analysis

Xuan Liu; Kang Zhang; Yong Huang; Jin U. Kang

doi:10.1364/BOE.2.002995

Spectroscopic-speckle variance OCT for microvasculature detection and analysis

Xuan Liu^*, Kang Zhang, Yong Huang, Jin U. Kang

^*Corresponding author for this work

Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

We propose and studied optical coherence tomography (OCT) combining spectroscopic (SOCT) and speckle variance (svOCT) functions to effectively detect locations of microvasculatures and assess blood oxygen saturation level. Chorioallantoic membrane of a chick embryo was imaged in vivo to perform the analysis of the system. We also studied the effect of speckle in spectral domain using experimental data and performed time-averaging to reduce speckle noise locally. We combined SOCT and svOCT images using hue, saturation and value (HSV) color map to show the localized spectroscopic property of blood. Results show distinct spectroscopic properties between arterial blood and capillary blood.

Original language	English
Pages (from-to)	2995-3009
Number of pages	15
Journal	Biomedical Optics Express
Volume	2
Issue number	11
DOIs	https://doi.org/10.1364/BOE.2.002995
Publication status	Published - 2011
Externally published	Yes

Access to Document

10.1364/BOE.2.002995

Cite this

@article{8d4d85f862fb4f6d8fe561a508ee75e8,

title = "Spectroscopic-speckle variance OCT for microvasculature detection and analysis",

abstract = "We propose and studied optical coherence tomography (OCT) combining spectroscopic (SOCT) and speckle variance (svOCT) functions to effectively detect locations of microvasculatures and assess blood oxygen saturation level. Chorioallantoic membrane of a chick embryo was imaged in vivo to perform the analysis of the system. We also studied the effect of speckle in spectral domain using experimental data and performed time-averaging to reduce speckle noise locally. We combined SOCT and svOCT images using hue, saturation and value (HSV) color map to show the localized spectroscopic property of blood. Results show distinct spectroscopic properties between arterial blood and capillary blood.",

author = "Xuan Liu and Kang Zhang and Yong Huang and Kang, \{Jin U.\}",

year = "2011",

doi = "10.1364/BOE.2.002995",

language = "English",

volume = "2",

pages = "2995--3009",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "Optica Publishing Group (formerly OSA)",

number = "11",

}

TY - JOUR

T1 - Spectroscopic-speckle variance OCT for microvasculature detection and analysis

AU - Liu, Xuan

AU - Zhang, Kang

AU - Huang, Yong

AU - Kang, Jin U.

PY - 2011

Y1 - 2011

N2 - We propose and studied optical coherence tomography (OCT) combining spectroscopic (SOCT) and speckle variance (svOCT) functions to effectively detect locations of microvasculatures and assess blood oxygen saturation level. Chorioallantoic membrane of a chick embryo was imaged in vivo to perform the analysis of the system. We also studied the effect of speckle in spectral domain using experimental data and performed time-averaging to reduce speckle noise locally. We combined SOCT and svOCT images using hue, saturation and value (HSV) color map to show the localized spectroscopic property of blood. Results show distinct spectroscopic properties between arterial blood and capillary blood.

AB - We propose and studied optical coherence tomography (OCT) combining spectroscopic (SOCT) and speckle variance (svOCT) functions to effectively detect locations of microvasculatures and assess blood oxygen saturation level. Chorioallantoic membrane of a chick embryo was imaged in vivo to perform the analysis of the system. We also studied the effect of speckle in spectral domain using experimental data and performed time-averaging to reduce speckle noise locally. We combined SOCT and svOCT images using hue, saturation and value (HSV) color map to show the localized spectroscopic property of blood. Results show distinct spectroscopic properties between arterial blood and capillary blood.

UR - https://www.scopus.com/pages/publications/84863098079

U2 - 10.1364/BOE.2.002995

DO - 10.1364/BOE.2.002995

M3 - Article

AN - SCOPUS:84863098079

SN - 2156-7085

VL - 2

SP - 2995

EP - 3009

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 11

ER -

Spectroscopic-speckle variance OCT for microvasculature detection and analysis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this