Solid-state low-threshold hemispherical shell-shaped protein whispering-gallery mode laser

Zibo Meng; Jiajia Meng; Gaoshang Li; Xiaolu Cui; Jiyang Ma; Bowen Li; Xubiao Peng; Qing Zhao

doi:10.1364/OE.571115

Solid-state low-threshold hemispherical shell-shaped protein whispering-gallery mode laser

Zibo Meng
, Jiajia Meng
, Gaoshang Li
, Xiaolu Cui
, Jiyang Ma
, Bowen Li
, Xubiao Peng
, Qing Zhao

School of Physics

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Protein-based whispering-gallery mode (WGM) lasers offer great potential for biosensing due to their biodegradability, biocompatibility, and non-toxicity. Here, we report a solid-state hemispherical shell–shaped protein WGM laser (hspWGM laser) made by forming silk fibroin shells on glass substrates and coating them with red fluorescent protein mCherry. The device (∼1.5 mm diameter) demonstrated stable lasing, short-term room-temperature storage, and a low lasing threshold (10.17 µJ/mm²). Central wavelength characteristics were tunable by adjusting device geometry. These results provide a foundation for developing biodegradable, protein-based biosensors and implantable optical devices.

Original language	English
Pages (from-to)	41558-41568
Number of pages	11
Journal	Optics Express
Volume	33
Issue number	20
DOIs	https://doi.org/10.1364/OE.571115
Publication status	Published - 6 Oct 2025

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title = "Solid-state low-threshold hemispherical shell-shaped protein whispering-gallery mode laser",

abstract = "Protein-based whispering-gallery mode (WGM) lasers offer great potential for biosensing due to their biodegradability, biocompatibility, and non-toxicity. Here, we report a solid-state hemispherical shell–shaped protein WGM laser (hspWGM laser) made by forming silk fibroin shells on glass substrates and coating them with red fluorescent protein mCherry. The device (∼1.5 mm diameter) demonstrated stable lasing, short-term room-temperature storage, and a low lasing threshold (10.17 µJ/mm2). Central wavelength characteristics were tunable by adjusting device geometry. These results provide a foundation for developing biodegradable, protein-based biosensors and implantable optical devices.",

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AU - Meng, Zibo

AU - Meng, Jiajia

AU - Li, Gaoshang

AU - Cui, Xiaolu

AU - Ma, Jiyang

AU - Li, Bowen

AU - Peng, Xubiao

AU - Zhao, Qing

PY - 2025/10/6

Y1 - 2025/10/6

N2 - Protein-based whispering-gallery mode (WGM) lasers offer great potential for biosensing due to their biodegradability, biocompatibility, and non-toxicity. Here, we report a solid-state hemispherical shell–shaped protein WGM laser (hspWGM laser) made by forming silk fibroin shells on glass substrates and coating them with red fluorescent protein mCherry. The device (∼1.5 mm diameter) demonstrated stable lasing, short-term room-temperature storage, and a low lasing threshold (10.17 µJ/mm2). Central wavelength characteristics were tunable by adjusting device geometry. These results provide a foundation for developing biodegradable, protein-based biosensors and implantable optical devices.

AB - Protein-based whispering-gallery mode (WGM) lasers offer great potential for biosensing due to their biodegradability, biocompatibility, and non-toxicity. Here, we report a solid-state hemispherical shell–shaped protein WGM laser (hspWGM laser) made by forming silk fibroin shells on glass substrates and coating them with red fluorescent protein mCherry. The device (∼1.5 mm diameter) demonstrated stable lasing, short-term room-temperature storage, and a low lasing threshold (10.17 µJ/mm2). Central wavelength characteristics were tunable by adjusting device geometry. These results provide a foundation for developing biodegradable, protein-based biosensors and implantable optical devices.

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JO - Optics Express

JF - Optics Express

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ER -

Solid-state low-threshold hemispherical shell-shaped protein whispering-gallery mode laser

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