TY - JOUR
T1 - Smart drug delivery systems for precise cancer therapy
AU - Wang, Xiaoyou
AU - Li, Chong
AU - Wang, Yiguang
AU - Chen, Huabing
AU - Zhang, Xinxin
AU - Luo, Cong
AU - Zhou, Wenhu
AU - Li, Lili
AU - Teng, Lesheng
AU - Yu, Haijun
AU - Wang, Jiancheng
N1 - Publisher Copyright:
© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences
PY - 2022/11
Y1 - 2022/11
N2 - Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics profiles, and in vivo distributions of anticancer nano-drug delivery systems. However, problems still exist in the delicate balance between improved anticancer efficacy and reduced toxicity to normal tissues, and opportunities arise along with the development of smart stimuli-responsive delivery strategies. By on-demand responsiveness towards exogenous or endogenous stimulus, these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner. Meanwhile, the blossom of nanotechnology, material sciences, and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics, versatile functions, and modification possibilities. This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems. It may provide references for researchers in the fields of drug delivery, biomaterials, and nanotechnology.
AB - Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics profiles, and in vivo distributions of anticancer nano-drug delivery systems. However, problems still exist in the delicate balance between improved anticancer efficacy and reduced toxicity to normal tissues, and opportunities arise along with the development of smart stimuli-responsive delivery strategies. By on-demand responsiveness towards exogenous or endogenous stimulus, these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner. Meanwhile, the blossom of nanotechnology, material sciences, and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics, versatile functions, and modification possibilities. This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems. It may provide references for researchers in the fields of drug delivery, biomaterials, and nanotechnology.
KW - Cancer
KW - Nano-drug delivery systems
KW - Pharmaceutics
KW - Precise therapy
KW - Receptor-ligand-based delivery
KW - Smart drug delivery system
KW - Stimuli-responsive
KW - Toxicity
UR - https://www.scopus.com/pages/publications/85139188633
U2 - 10.1016/j.apsb.2022.08.013
DO - 10.1016/j.apsb.2022.08.013
M3 - Review article
AN - SCOPUS:85139188633
SN - 2211-3835
VL - 12
SP - 4098
EP - 4121
JO - Acta Pharmaceutica Sinica B
JF - Acta Pharmaceutica Sinica B
IS - 11
ER -