Six new polyhydroxy steroidal glycosides from Dregea sinensis Hemsl

Shaohua Jia; Xiujie Liu; Rongji Dai; Weiwei Meng; Yan Chen; Yulin Deng; Fang Lv

doi:10.1016/j.phytol.2014.12.016

Six new polyhydroxy steroidal glycosides from Dregea sinensis Hemsl

Shaohua Jia, Xiujie Liu, Rongji Dai, Weiwei Meng, Yan Chen, Yulin Deng, Fang Lv^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The phytochemical investigation of the roots of Dregea sinensis Hemsl yielded six new polyhydroxy steroidal glycosides (1-6). The chemical structures have been elucidated on the basis of extensive one- and two-dimensional NMR spectroscopy, as well as by mass spectrometry. The cytotoxic activity of these compounds were evaluated in vitro while compounds 3 and 4 showed weak activity against human leukemia cells (HL-60) with IC₅₀ values of 14.10 μM and 19.16 μM, respectively.

Original language	English
Pages (from-to)	209-214
Number of pages	6
Journal	Phytochemistry Letters
Volume	11
DOIs	https://doi.org/10.1016/j.phytol.2014.12.016
Publication status	Published - Mar 2015

Keywords

Asclepiadaceae
Cytotoxic activity
Dregea sinensis Hemsl
Steroidal glycosides

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10.1016/j.phytol.2014.12.016

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title = "Six new polyhydroxy steroidal glycosides from Dregea sinensis Hemsl",

abstract = "The phytochemical investigation of the roots of Dregea sinensis Hemsl yielded six new polyhydroxy steroidal glycosides (1-6). The chemical structures have been elucidated on the basis of extensive one- and two-dimensional NMR spectroscopy, as well as by mass spectrometry. The cytotoxic activity of these compounds were evaluated in vitro while compounds 3 and 4 showed weak activity against human leukemia cells (HL-60) with IC50 values of 14.10 μM and 19.16 μM, respectively.",

keywords = "Asclepiadaceae, Cytotoxic activity, Dregea sinensis Hemsl, Steroidal glycosides",

author = "Shaohua Jia and Xiujie Liu and Rongji Dai and Weiwei Meng and Yan Chen and Yulin Deng and Fang Lv",

note = "Publisher Copyright: {\textcopyright} 2015 Published by Elsevier B.V. on behalf of Phytochemical Society of Europe.",

year = "2015",

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doi = "10.1016/j.phytol.2014.12.016",

language = "English",

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journal = "Phytochemistry Letters",

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T1 - Six new polyhydroxy steroidal glycosides from Dregea sinensis Hemsl

AU - Jia, Shaohua

AU - Liu, Xiujie

AU - Dai, Rongji

AU - Meng, Weiwei

AU - Chen, Yan

AU - Deng, Yulin

AU - Lv, Fang

PY - 2015/3

Y1 - 2015/3

N2 - The phytochemical investigation of the roots of Dregea sinensis Hemsl yielded six new polyhydroxy steroidal glycosides (1-6). The chemical structures have been elucidated on the basis of extensive one- and two-dimensional NMR spectroscopy, as well as by mass spectrometry. The cytotoxic activity of these compounds were evaluated in vitro while compounds 3 and 4 showed weak activity against human leukemia cells (HL-60) with IC50 values of 14.10 μM and 19.16 μM, respectively.

AB - The phytochemical investigation of the roots of Dregea sinensis Hemsl yielded six new polyhydroxy steroidal glycosides (1-6). The chemical structures have been elucidated on the basis of extensive one- and two-dimensional NMR spectroscopy, as well as by mass spectrometry. The cytotoxic activity of these compounds were evaluated in vitro while compounds 3 and 4 showed weak activity against human leukemia cells (HL-60) with IC50 values of 14.10 μM and 19.16 μM, respectively.

KW - Asclepiadaceae

KW - Cytotoxic activity

KW - Dregea sinensis Hemsl

KW - Steroidal glycosides

UR - https://www.scopus.com/pages/publications/84920736061

U2 - 10.1016/j.phytol.2014.12.016

DO - 10.1016/j.phytol.2014.12.016

M3 - Article

AN - SCOPUS:84920736061

SN - 1874-3900

VL - 11

SP - 209

EP - 214

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Six new polyhydroxy steroidal glycosides from Dregea sinensis Hemsl

Abstract

Keywords

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