Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

Fang Lv; Xueying Wu; Jin Song; Pan Wang; Shucheng Ren; Wei Guo; Qi Xue; Henghui Zhang; Jun Zhao

doi:10.1186/s40364-021-00287-8

Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

Fang Lv
, Xueying Wu
, Jin Song
, Pan Wang
, Shucheng Ren
, Wei Guo
, Qi Xue^*
, Henghui Zhang^*
, Jun Zhao^*

^*Corresponding author for this work

Chinese Academy of Medical Sciences
Capital Medical University
Immupeutics Medicine Institute

Research output: Contribution to journal › Letter › peer-review

2 Citations (Scopus)

Abstract

It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.

Original language	English
Article number	41
Journal	Biomarker Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s40364-021-00287-8
Publication status	Published - Dec 2021
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Lung adenocarcinoma
Single‐cell RNA sequencing
Tumor associated antigens

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10.1186/s40364-021-00287-8

Cite this

@article{397056a8c95a43bf92398ce65f0ed5b4,

title = "Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)",

abstract = "It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.",

keywords = "Lung adenocarcinoma, Single‐cell RNA sequencing, Tumor associated antigens",

author = "Fang Lv and Xueying Wu and Jin Song and Pan Wang and Shucheng Ren and Wei Guo and Qi Xue and Henghui Zhang and Jun Zhao",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1186/s40364-021-00287-8",

language = "English",

volume = "9",

journal = "Biomarker Research",

issn = "2050-7771",

publisher = "BioMed Central Ltd.",

number = "1",

}

TY - JOUR

T1 - Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

AU - Lv, Fang

AU - Wu, Xueying

AU - Song, Jin

AU - Wang, Pan

AU - Ren, Shucheng

AU - Guo, Wei

AU - Xue, Qi

AU - Zhang, Henghui

AU - Zhao, Jun

PY - 2021/12

Y1 - 2021/12

N2 - It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.

AB - It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.

KW - Lung adenocarcinoma

KW - Single‐cell RNA sequencing

KW - Tumor associated antigens

UR - https://www.scopus.com/pages/publications/85107180018

U2 - 10.1186/s40364-021-00287-8

DO - 10.1186/s40364-021-00287-8

M3 - Letter

AN - SCOPUS:85107180018

SN - 2050-7771

VL - 9

JO - Biomarker Research

JF - Biomarker Research

IS - 1

M1 - 41

ER -

Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

Abstract

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Keywords

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