Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

Fang Lv; Xueying Wu; Jin Song; Pan Wang; Shucheng Ren; Wei Guo; Qi Xue; Henghui Zhang; Jun Zhao

doi:10.1186/s40364-021-00287-8

Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

Fang Lv, Xueying Wu, Jin Song, Pan Wang, Shucheng Ren, Wei Guo, Qi Xue^*, Henghui Zhang^*, Jun Zhao^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

Abstract

It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.

Original language	English
Article number	41
Journal	Biomarker Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s40364-021-00287-8
Publication status	Published - Dec 2021
Externally published	Yes

Keywords

Lung adenocarcinoma
Single‐cell RNA sequencing
Tumor associated antigens

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s40364-021-00287-8

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title = "Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)",

abstract = "It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.",

keywords = "Lung adenocarcinoma, Single‐cell RNA sequencing, Tumor associated antigens",

author = "Fang Lv and Xueying Wu and Jin Song and Pan Wang and Shucheng Ren and Wei Guo and Qi Xue and Henghui Zhang and Jun Zhao",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1186/s40364-021-00287-8",

language = "English",

volume = "9",

journal = "Biomarker Research",

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TY - JOUR

T1 - Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

AU - Lv, Fang

AU - Wu, Xueying

AU - Song, Jin

AU - Wang, Pan

AU - Ren, Shucheng

AU - Guo, Wei

AU - Xue, Qi

AU - Zhang, Henghui

AU - Zhao, Jun

PY - 2021/12

Y1 - 2021/12

N2 - It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.

AB - It has been suggested that the heterogeneity of TAAs in lung cancer may affect the therapeutic response and disease progression. Up to now, several tumor-associated antigen (TAA)-based cancer vaccines have been investigated in lung adenocarcinoma (LUAD); however, most of them have failed at the stage of clinical trials. The present study suggests that inter-tumoral heterogeneity of TAAs is large at single-cell resolution, while the communication between tumor cells and infiltrating T cells is closely related to the expression profile of TAAs.

KW - Lung adenocarcinoma

KW - Single‐cell RNA sequencing

KW - Tumor associated antigens

UR - http://www.scopus.com/inward/record.url?scp=85107180018&partnerID=8YFLogxK

U2 - 10.1186/s40364-021-00287-8

DO - 10.1186/s40364-021-00287-8

M3 - Letter

AN - SCOPUS:85107180018

SN - 2050-7771

VL - 9

JO - Biomarker Research

JF - Biomarker Research

IS - 1

M1 - 41

ER -

Single cell transcriptome revealed tumor associated antigen (TAA) profile in lung adenocarcinoma (LUAD)

Abstract

Keywords

UN SDGs

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