Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer

Kan Lin; Wei Zheng; Jianfeng Wang; Chwee Ming Lim; Zhiwei Huang

doi:10.1117/12.2213964

Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer

Kan Lin, Wei Zheng, Jianfeng Wang, Chwee Ming Lim, Zhiwei Huang^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic confocal Raman spectroscopy for in vivo diagnosis of laryngeal cancer in the head and neck under wide-field endoscopic imaging. The simultaneous FP and HW Raman endoscopy technique was performed on 21 patients and differentiated laryngeal carcinoma from normal tissues with both sensitivity and specificity of ∼85%. This study shows the great potential of the FP/HW Raman endoscopic technique developed for in vivo diagnosis of laryngeal carcinoma during routine endoscopic examination.

Original language	English
Title of host publication	Photonic Therapeutics and Diagnostics XII
Editors	Bernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Guillermo J. Tearney, Kenton W. Gregory, Laura Marcu, Melissa C. Skala, Paul J. Campagnola, Andreas Mandelis
Publisher	SPIE
ISBN (Electronic)	9781628419245
DOIs	https://doi.org/10.1117/12.2213964
Publication status	Published - 2016
Externally published	Yes
Event	Photonic Therapeutics and Diagnostics XII - San Francisco, United States Duration: 13 Feb 2016 → 14 Feb 2016

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9689
ISSN (Print)	1605-7422

Conference

Conference	Photonic Therapeutics and Diagnostics XII
Country/Territory	United States
City	San Francisco
Period	13/02/16 → 14/02/16

Keywords

Raman spectroscopy
endoscopy
fingerprint
high-wavenumber
laryngeal cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.2213964

Cite this

Lin, K., Zheng, W., Wang, J., Lim, C. M., & Huang, Z. (2016). Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer. In B. Choi, N. Kollias, H. Zeng, H. W. Kang, B. J. F. Wong, J. F. Ilgner, G. J. Tearney, K. W. Gregory, L. Marcu, M. C. Skala, P. J. Campagnola, & A. Mandelis (Eds.), Photonic Therapeutics and Diagnostics XII Article 96892B (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9689). SPIE. https://doi.org/10.1117/12.2213964

Lin, Kan ; Zheng, Wei ; Wang, Jianfeng et al. / Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer. Photonic Therapeutics and Diagnostics XII. editor / Bernard Choi ; Nikiforos Kollias ; Haishan Zeng ; Hyun Wook Kang ; Brian J. F. Wong ; Justus F. Ilgner ; Guillermo J. Tearney ; Kenton W. Gregory ; Laura Marcu ; Melissa C. Skala ; Paul J. Campagnola ; Andreas Mandelis. SPIE, 2016. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer",

abstract = "We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic confocal Raman spectroscopy for in vivo diagnosis of laryngeal cancer in the head and neck under wide-field endoscopic imaging. The simultaneous FP and HW Raman endoscopy technique was performed on 21 patients and differentiated laryngeal carcinoma from normal tissues with both sensitivity and specificity of ∼85\%. This study shows the great potential of the FP/HW Raman endoscopic technique developed for in vivo diagnosis of laryngeal carcinoma during routine endoscopic examination.",

keywords = "Raman spectroscopy, endoscopy, fingerprint, high-wavenumber, laryngeal cancer",

author = "Kan Lin and Wei Zheng and Jianfeng Wang and Lim, \{Chwee Ming\} and Zhiwei Huang",

note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Photonic Therapeutics and Diagnostics XII ; Conference date: 13-02-2016 Through 14-02-2016",

year = "2016",

doi = "10.1117/12.2213964",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Bernard Choi and Nikiforos Kollias and Haishan Zeng and Kang, \{Hyun Wook\} and Wong, \{Brian J. F.\} and Ilgner, \{Justus F.\} and Tearney, \{Guillermo J.\} and Gregory, \{Kenton W.\} and Laura Marcu and Skala, \{Melissa C.\} and Campagnola, \{Paul J.\} and Andreas Mandelis",

booktitle = "Photonic Therapeutics and Diagnostics XII",

address = "United States",

}

Lin, K, Zheng, W, Wang, J, Lim, CM & Huang, Z 2016, Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer. in B Choi, N Kollias, H Zeng, HW Kang, BJF Wong, JF Ilgner, GJ Tearney, KW Gregory, L Marcu, MC Skala, PJ Campagnola & A Mandelis (eds), Photonic Therapeutics and Diagnostics XII., 96892B, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9689, SPIE, Photonic Therapeutics and Diagnostics XII, San Francisco, United States, 13/02/16. https://doi.org/10.1117/12.2213964

Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer. / Lin, Kan; Zheng, Wei; Wang, Jianfeng et al.
Photonic Therapeutics and Diagnostics XII. ed. / Bernard Choi; Nikiforos Kollias; Haishan Zeng; Hyun Wook Kang; Brian J. F. Wong; Justus F. Ilgner; Guillermo J. Tearney; Kenton W. Gregory; Laura Marcu; Melissa C. Skala; Paul J. Campagnola; Andreas Mandelis. SPIE, 2016. 96892B (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9689).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer

AU - Lin, Kan

AU - Zheng, Wei

AU - Wang, Jianfeng

AU - Lim, Chwee Ming

AU - Huang, Zhiwei

PY - 2016

Y1 - 2016

N2 - We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic confocal Raman spectroscopy for in vivo diagnosis of laryngeal cancer in the head and neck under wide-field endoscopic imaging. The simultaneous FP and HW Raman endoscopy technique was performed on 21 patients and differentiated laryngeal carcinoma from normal tissues with both sensitivity and specificity of ∼85%. This study shows the great potential of the FP/HW Raman endoscopic technique developed for in vivo diagnosis of laryngeal carcinoma during routine endoscopic examination.

AB - We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic confocal Raman spectroscopy for in vivo diagnosis of laryngeal cancer in the head and neck under wide-field endoscopic imaging. The simultaneous FP and HW Raman endoscopy technique was performed on 21 patients and differentiated laryngeal carcinoma from normal tissues with both sensitivity and specificity of ∼85%. This study shows the great potential of the FP/HW Raman endoscopic technique developed for in vivo diagnosis of laryngeal carcinoma during routine endoscopic examination.

KW - Raman spectroscopy

KW - endoscopy

KW - fingerprint

KW - high-wavenumber

KW - laryngeal cancer

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U2 - 10.1117/12.2213964

DO - 10.1117/12.2213964

M3 - Conference contribution

AN - SCOPUS:85051752757

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics XII

A2 - Choi, Bernard

A2 - Kollias, Nikiforos

A2 - Zeng, Haishan

A2 - Kang, Hyun Wook

A2 - Wong, Brian J. F.

A2 - Ilgner, Justus F.

A2 - Tearney, Guillermo J.

A2 - Gregory, Kenton W.

A2 - Marcu, Laura

A2 - Skala, Melissa C.

A2 - Campagnola, Paul J.

A2 - Mandelis, Andreas

PB - SPIE

T2 - Photonic Therapeutics and Diagnostics XII

Y2 - 13 February 2016 through 14 February 2016

ER -

Lin K, Zheng W, Wang J, Lim CM, Huang Z. Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer. In Choi B, Kollias N, Zeng H, Kang HW, Wong BJF, Ilgner JF, Tearney GJ, Gregory KW, Marcu L, Skala MC, Campagnola PJ, Mandelis A, editors, Photonic Therapeutics and Diagnostics XII. SPIE. 2016. 96892B. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2213964

Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer

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Keywords

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