Self-reporting liposomes for intracellular drug release

Wansong Chen; Qiyu Huang; Weizhu Ou; Yuanqiang Hao; Liqiang Wang; Ke Zeng; Hongyan Guo; Juan Li; You Nian Liu

doi:10.1002/smll.201302698

Self-reporting liposomes for intracellular drug release

Wansong Chen, Qiyu Huang, Weizhu Ou, Yuanqiang Hao, Liqiang Wang, Ke Zeng, Hongyan Guo, Juan Li^*, You Nian Liu

^*Corresponding author for this work

Central South University

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

A new liposomal carrier embedded with a ratiometric fluorescent probe PNO is prepared. The integrated liposomes (PNO-LIPs) exhibit blue fluorescence in serum. Triggered by the thiols exogenously or endogenously, PNO-LIPs collapse with a burst drug release and a concurrent fluorescence change from blue to green. Furthermore, DOX-loaded PNO-LIPs improve the intracellular drug bioavailability.

Original language	English
Pages (from-to)	1261-1265
Number of pages	5
Journal	Small
Volume	10
Issue number	7
DOIs	https://doi.org/10.1002/smll.201302698
Publication status	Published - 9 Apr 2014
Externally published	Yes

Keywords

drug delivery
fluorescence
liposomes
theranostic
thiol-responsive

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10.1002/smll.201302698

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AU - Chen, Wansong

AU - Huang, Qiyu

AU - Ou, Weizhu

AU - Hao, Yuanqiang

AU - Wang, Liqiang

AU - Zeng, Ke

AU - Guo, Hongyan

AU - Li, Juan

AU - Liu, You Nian

PY - 2014/4/9

Y1 - 2014/4/9

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AB - A new liposomal carrier embedded with a ratiometric fluorescent probe PNO is prepared. The integrated liposomes (PNO-LIPs) exhibit blue fluorescence in serum. Triggered by the thiols exogenously or endogenously, PNO-LIPs collapse with a burst drug release and a concurrent fluorescence change from blue to green. Furthermore, DOX-loaded PNO-LIPs improve the intracellular drug bioavailability.

KW - drug delivery

KW - fluorescence

KW - liposomes

KW - theranostic

KW - thiol-responsive

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DO - 10.1002/smll.201302698

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JO - Small

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IS - 7

ER -

Self-reporting liposomes for intracellular drug release

Abstract

Keywords

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