Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1

Yingzi Zhang; Lingling Xu; Zhuo Liu; Xi Cui; Zhuo Xiang; Jinyu Bai; Dongjie Jiang; Jiangtao Xue; Chan Wang; Youxi Lin; Zhe Li; Yizhu Shan; Yuan Yang; Lin Bo; Zhou Li; Xiaozhong Zhou

doi:10.1016/j.nanoen.2021.106009

Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1

Yingzi Zhang
, Lingling Xu
, Zhuo Liu
, Xi Cui
, Zhuo Xiang
, Jinyu Bai
, Dongjie Jiang
, Jiangtao Xue
, Chan Wang
, Youxi Lin
, Zhe Li
, Yizhu Shan
, Yuan Yang
, Lin Bo^*
, Zhou Li
, Xiaozhong Zhou^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Promoting the differentiation of osteoblasts is critical to maintain bone homeostasis for treatment osteoporosis and fracture healing. For these orthopedic diseases, a portable, highly patient compliance therapy device remains a great challenge. Here, we proposed a biomechanical-energy-driven shape memory piezoelectric nanogenerator (sm-PENG) that integrated with fixation splint to promote osteogenic differentiation. The pulsed direct current (DC) generated from the sm-PENG effectively promote MC3T3-E1 preosteoblast cell proliferation, orientation and increase intracellular calcium ion. At the same time, the ALP activity of cells is also improved by pulsed-DC under long-term culture conditions. Ultimately, increasing calcium deposition, extracellular matrix mineralization and osteogenesis. Our work demonstrates the potential of sm-PENG as a power source for pulsed-DC stimulation of bone repair, and shows great prospect self-powered and portable electronic medical device.

Original language	English
Article number	106009
Journal	Nano Energy
Volume	85
DOIs	https://doi.org/10.1016/j.nanoen.2021.106009
Publication status	Published - Jul 2021
Externally published	Yes

Keywords

Electrical stimulation
Nanogenerator
Osteoblast
Pulsed direct current
Self-powered

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10.1016/j.nanoen.2021.106009

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@article{22d591f9476a48afbaf4ba60a40b7182,

title = "Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1",

abstract = "Promoting the differentiation of osteoblasts is critical to maintain bone homeostasis for treatment osteoporosis and fracture healing. For these orthopedic diseases, a portable, highly patient compliance therapy device remains a great challenge. Here, we proposed a biomechanical-energy-driven shape memory piezoelectric nanogenerator (sm-PENG) that integrated with fixation splint to promote osteogenic differentiation. The pulsed direct current (DC) generated from the sm-PENG effectively promote MC3T3-E1 preosteoblast cell proliferation, orientation and increase intracellular calcium ion. At the same time, the ALP activity of cells is also improved by pulsed-DC under long-term culture conditions. Ultimately, increasing calcium deposition, extracellular matrix mineralization and osteogenesis. Our work demonstrates the potential of sm-PENG as a power source for pulsed-DC stimulation of bone repair, and shows great prospect self-powered and portable electronic medical device.",

keywords = "Electrical stimulation, Nanogenerator, Osteoblast, Pulsed direct current, Self-powered",

author = "Yingzi Zhang and Lingling Xu and Zhuo Liu and Xi Cui and Zhuo Xiang and Jinyu Bai and Dongjie Jiang and Jiangtao Xue and Chan Wang and Youxi Lin and Zhe Li and Yizhu Shan and Yuan Yang and Lin Bo and Zhou Li and Xiaozhong Zhou",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = jul,

doi = "10.1016/j.nanoen.2021.106009",

language = "English",

volume = "85",

journal = "Nano Energy",

issn = "2211-2855",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1

AU - Zhang, Yingzi

AU - Xu, Lingling

AU - Liu, Zhuo

AU - Cui, Xi

AU - Xiang, Zhuo

AU - Bai, Jinyu

AU - Jiang, Dongjie

AU - Xue, Jiangtao

AU - Wang, Chan

AU - Lin, Youxi

AU - Li, Zhe

AU - Shan, Yizhu

AU - Yang, Yuan

AU - Bo, Lin

AU - Li, Zhou

AU - Zhou, Xiaozhong

PY - 2021/7

Y1 - 2021/7

N2 - Promoting the differentiation of osteoblasts is critical to maintain bone homeostasis for treatment osteoporosis and fracture healing. For these orthopedic diseases, a portable, highly patient compliance therapy device remains a great challenge. Here, we proposed a biomechanical-energy-driven shape memory piezoelectric nanogenerator (sm-PENG) that integrated with fixation splint to promote osteogenic differentiation. The pulsed direct current (DC) generated from the sm-PENG effectively promote MC3T3-E1 preosteoblast cell proliferation, orientation and increase intracellular calcium ion. At the same time, the ALP activity of cells is also improved by pulsed-DC under long-term culture conditions. Ultimately, increasing calcium deposition, extracellular matrix mineralization and osteogenesis. Our work demonstrates the potential of sm-PENG as a power source for pulsed-DC stimulation of bone repair, and shows great prospect self-powered and portable electronic medical device.

AB - Promoting the differentiation of osteoblasts is critical to maintain bone homeostasis for treatment osteoporosis and fracture healing. For these orthopedic diseases, a portable, highly patient compliance therapy device remains a great challenge. Here, we proposed a biomechanical-energy-driven shape memory piezoelectric nanogenerator (sm-PENG) that integrated with fixation splint to promote osteogenic differentiation. The pulsed direct current (DC) generated from the sm-PENG effectively promote MC3T3-E1 preosteoblast cell proliferation, orientation and increase intracellular calcium ion. At the same time, the ALP activity of cells is also improved by pulsed-DC under long-term culture conditions. Ultimately, increasing calcium deposition, extracellular matrix mineralization and osteogenesis. Our work demonstrates the potential of sm-PENG as a power source for pulsed-DC stimulation of bone repair, and shows great prospect self-powered and portable electronic medical device.

KW - Electrical stimulation

KW - Nanogenerator

KW - Osteoblast

KW - Pulsed direct current

KW - Self-powered

UR - https://www.scopus.com/pages/publications/85103082973

U2 - 10.1016/j.nanoen.2021.106009

DO - 10.1016/j.nanoen.2021.106009

M3 - Article

AN - SCOPUS:85103082973

SN - 2211-2855

VL - 85

JO - Nano Energy

JF - Nano Energy

M1 - 106009

ER -

Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1

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Keywords

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