TY - GEN
T1 - Self-assembly of toroidal magnetic microstructures towards in vitro cell structures
AU - Takeuchi, Masaru
AU - Hattori, Mamoru
AU - Ichikawa, Akihiko
AU - Ohara, Kenichi
AU - Nakajima, Masahiro
AU - Fukuda, Toshio
AU - Hasegawa, Yasuhisa
AU - Huang, Qiang
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/11/28
Y1 - 2016/11/28
N2 - In this paper, we propose a new method to assemble microstructures with biological cells towards in vitro 3D cellular structures. The proposed assembly method uses self-assembly process of magnetized toroidal microstructures. Biocompatible toroidal hydrogel microstructures are prepared by electrodeposition method, and ferrite particles are put on the fabricated structures using poly-L-lysine (PLL). The microstructures are magnetized by the magnetic field at 3 T, and assembled by the magnetic self-assembly process. Biological cells were encapsulated in the microstructures and cultured to achieve high density of cells inside structures. The magnetized microstructures were assembled automatically. The magnetic force generated from the ferrite embedded microstructures was estimated and compared to the fluid resistance applied to the microstructures. The proposed method can be applied to achieve 3D in vitro cell structures with vascular networks for tissue engineering applications.
AB - In this paper, we propose a new method to assemble microstructures with biological cells towards in vitro 3D cellular structures. The proposed assembly method uses self-assembly process of magnetized toroidal microstructures. Biocompatible toroidal hydrogel microstructures are prepared by electrodeposition method, and ferrite particles are put on the fabricated structures using poly-L-lysine (PLL). The microstructures are magnetized by the magnetic field at 3 T, and assembled by the magnetic self-assembly process. Biological cells were encapsulated in the microstructures and cultured to achieve high density of cells inside structures. The magnetized microstructures were assembled automatically. The magnetic force generated from the ferrite embedded microstructures was estimated and compared to the fluid resistance applied to the microstructures. The proposed method can be applied to achieve 3D in vitro cell structures with vascular networks for tissue engineering applications.
UR - http://www.scopus.com/inward/record.url?scp=85006356420&partnerID=8YFLogxK
U2 - 10.1109/IROS.2016.7759401
DO - 10.1109/IROS.2016.7759401
M3 - Conference contribution
AN - SCOPUS:85006356420
T3 - IEEE International Conference on Intelligent Robots and Systems
SP - 2578
EP - 2583
BT - IROS 2016 - 2016 IEEE/RSJ International Conference on Intelligent Robots and Systems
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2016 IEEE/RSJ International Conference on Intelligent Robots and Systems, IROS 2016
Y2 - 9 October 2016 through 14 October 2016
ER -