Self-assembly of magnetized microstructures for in vitro cell systems

Mamoru Hattori, Akihiko Ichikawa, Kenichi Ohara, Toshio Fukuda, Masaru Takeuchi, Masahiro Nakajima, Yasuhisa Hasegawa, Qiang Huang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

In this paper, we conducted to assembly of microstructures for in vitro 3D cellular structures using self-assembly of magnetized hydrogels. The biocompatible hydrogel microstructures are fabricated by electrodeposition method and ferrite particles are coated on the structures with poly-L-lysine. The microstructures are magnetized by applying 3 T magnetic field, and assembled by the magnetic force. Biological cells can be encapsulated in the microstructures and cultured to achieve high density cell structures. The magnetic microstructures were assembled automatically to form tube structures. The magnetic force generated from the ferrite embedded microstructures was estimated and compared to the fluid resistance applied to the microstructures. The assembly of microstructures was achieved using a shaker to shake the structures inside liquid. The proposed method can be applied to assemble 3D cell structures with vascular-like channels for tissue engineering applications.

Original languageEnglish
Title of host publication2016 IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages635-640
Number of pages6
ISBN (Electronic)9781509023943
DOIs
Publication statusPublished - 1 Sept 2016
Event13th IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016 - Harbin, Heilongjiang, China
Duration: 7 Aug 201610 Aug 2016

Publication series

Name2016 IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016

Conference

Conference13th IEEE International Conference on Mechatronics and Automation, IEEE ICMA 2016
Country/TerritoryChina
CityHarbin, Heilongjiang
Period7/08/1610/08/16

Keywords

  • Magnetic force
  • Self-assembly
  • Tissue Engineering

Fingerprint

Dive into the research topics of 'Self-assembly of magnetized microstructures for in vitro cell systems'. Together they form a unique fingerprint.

Cite this