Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain

Shang Wu; Limin Zhang; Weizhi Wang

doi:10.1021/acs.analchem.2c02223

Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain

Shang Wu
, Limin Zhang
, Weizhi Wang^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.

Original language	English
Pages (from-to)	11464-11469
Number of pages	6
Journal	Analytical Chemistry
Volume	94
Issue number	33
DOIs	https://doi.org/10.1021/acs.analchem.2c02223
Publication status	Published - 23 Aug 2022

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10.1021/acs.analchem.2c02223

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title = "Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain",

abstract = "A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.",

author = "Shang Wu and Limin Zhang and Weizhi Wang",

year = "2022",

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AU - Wu, Shang

AU - Zhang, Limin

AU - Wang, Weizhi

PY - 2022/8/23

Y1 - 2022/8/23

N2 - A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.

AB - A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.

UR - https://www.scopus.com/pages/publications/85135192507

U2 - 10.1021/acs.analchem.2c02223

DO - 10.1021/acs.analchem.2c02223

M3 - Article

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SN - 0003-2700

VL - 94

SP - 11464

EP - 11469

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 33

ER -

Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain

Abstract

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