Ruthenium-catalyzed C-h oxygenation on aryl Weinreb amides

Fanzhi Yang; Lutz Ackermann

doi:10.1021/ol303520h

Ruthenium-catalyzed C-h oxygenation on aryl Weinreb amides

Fanzhi Yang, Lutz Ackermann^*

^*Corresponding author for this work

University of Göttingen

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

Versatile ruthenium catalysts enabled unprecedented C-H bond oxygenations of aryl Weinreb amides with ample scope under exceedingly mild reaction conditions, thereby also giving access to valuable ortho-hydroxylated aldehydes. Mechanistic studies provided strong support for a kinetically relevant C-H bond activation.

Original language	English
Pages (from-to)	718-720
Number of pages	3
Journal	Organic Letters
Volume	15
Issue number	3
DOIs	https://doi.org/10.1021/ol303520h
Publication status	Published - 1 Feb 2013
Externally published	Yes

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10.1021/ol303520h

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title = "Ruthenium-catalyzed C-h oxygenation on aryl Weinreb amides",

abstract = "Versatile ruthenium catalysts enabled unprecedented C-H bond oxygenations of aryl Weinreb amides with ample scope under exceedingly mild reaction conditions, thereby also giving access to valuable ortho-hydroxylated aldehydes. Mechanistic studies provided strong support for a kinetically relevant C-H bond activation.",

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AB - Versatile ruthenium catalysts enabled unprecedented C-H bond oxygenations of aryl Weinreb amides with ample scope under exceedingly mild reaction conditions, thereby also giving access to valuable ortho-hydroxylated aldehydes. Mechanistic studies provided strong support for a kinetically relevant C-H bond activation.

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Ruthenium-catalyzed C-h oxygenation on aryl Weinreb amides

Abstract

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