Role of white matter hyperintensities and related risk factors in vascular cognitive impairment: A review

Yiyi Chen; Xing Wang; Ling Guan; Yilong Wang

doi:10.3390/biom11081102

Role of white matter hyperintensities and related risk factors in vascular cognitive impairment: A review

Yiyi Chen, Xing Wang, Ling Guan, Yilong Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging markers of cerebral small-vessel disease, which is prevalent in older individuals and closely associated with the occurrence and development of cognitive impairment. The heterogeneous nature of the imaging manifestations of WMHs creates difficulties for early detection and diagnosis of vascular cognitive impairment (VCI) associated with WMHs. Because the underlying pathological processes and biomarkers of WMHs and their development in cognitive impairment remain uncertain, progress in prevention and treatment is lagging. For this reason, this paper reviews the status of research on the features of WMHs related to VCI, as well as mediators associated with both WMHs and VCI, and summarizes potential treatment strategies for the prevention and intervention in WMHs associated with VCI.

Original language	English
Article number	1102
Journal	Biomolecules
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/biom11081102
Publication status	Published - Aug 2021
Externally published	Yes

Keywords

Cerebral small vessel disease
Cognitive impairment
White matter hyperintensities

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10.3390/biom11081102

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title = "Role of white matter hyperintensities and related risk factors in vascular cognitive impairment: A review",

abstract = "White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging markers of cerebral small-vessel disease, which is prevalent in older individuals and closely associated with the occurrence and development of cognitive impairment. The heterogeneous nature of the imaging manifestations of WMHs creates difficulties for early detection and diagnosis of vascular cognitive impairment (VCI) associated with WMHs. Because the underlying pathological processes and biomarkers of WMHs and their development in cognitive impairment remain uncertain, progress in prevention and treatment is lagging. For this reason, this paper reviews the status of research on the features of WMHs related to VCI, as well as mediators associated with both WMHs and VCI, and summarizes potential treatment strategies for the prevention and intervention in WMHs associated with VCI.",

keywords = "Cerebral small vessel disease, Cognitive impairment, White matter hyperintensities",

author = "Yiyi Chen and Xing Wang and Ling Guan and Yilong Wang",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = aug,

doi = "10.3390/biom11081102",

language = "English",

volume = "11",

journal = "Biomolecules",

issn = "2218-273X",

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TY - JOUR

T1 - Role of white matter hyperintensities and related risk factors in vascular cognitive impairment

T2 - A review

AU - Chen, Yiyi

AU - Wang, Xing

AU - Guan, Ling

AU - Wang, Yilong

PY - 2021/8

Y1 - 2021/8

N2 - White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging markers of cerebral small-vessel disease, which is prevalent in older individuals and closely associated with the occurrence and development of cognitive impairment. The heterogeneous nature of the imaging manifestations of WMHs creates difficulties for early detection and diagnosis of vascular cognitive impairment (VCI) associated with WMHs. Because the underlying pathological processes and biomarkers of WMHs and their development in cognitive impairment remain uncertain, progress in prevention and treatment is lagging. For this reason, this paper reviews the status of research on the features of WMHs related to VCI, as well as mediators associated with both WMHs and VCI, and summarizes potential treatment strategies for the prevention and intervention in WMHs associated with VCI.

AB - White matter hyperintensities (WMHs) of presumed vascular origin are one of the imaging markers of cerebral small-vessel disease, which is prevalent in older individuals and closely associated with the occurrence and development of cognitive impairment. The heterogeneous nature of the imaging manifestations of WMHs creates difficulties for early detection and diagnosis of vascular cognitive impairment (VCI) associated with WMHs. Because the underlying pathological processes and biomarkers of WMHs and their development in cognitive impairment remain uncertain, progress in prevention and treatment is lagging. For this reason, this paper reviews the status of research on the features of WMHs related to VCI, as well as mediators associated with both WMHs and VCI, and summarizes potential treatment strategies for the prevention and intervention in WMHs associated with VCI.

KW - Cerebral small vessel disease

KW - Cognitive impairment

KW - White matter hyperintensities

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U2 - 10.3390/biom11081102

DO - 10.3390/biom11081102

M3 - Review article

C2 - 34439769

AN - SCOPUS:85111118591

SN - 2218-273X

VL - 11

JO - Biomolecules

JF - Biomolecules

IS - 8

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ER -

Role of white matter hyperintensities and related risk factors in vascular cognitive impairment: A review

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Keywords

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