Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

Anee Taj; Chen Cui; Zhenwei Shi; Xuebin Huang; Xiao Hui Yang

doi:10.1039/d5qo00926j

Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

Anee Taj
, Chen Cui
, Zhenwei Shi
, Xuebin Huang^*
, Xiao Hui Yang^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.

Original language	English
Pages (from-to)	6401-6406
Number of pages	6
Journal	Organic Chemistry Frontiers
Volume	12
Issue number	23
DOIs	https://doi.org/10.1039/d5qo00926j
Publication status	Published - 7 Dec 2025

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abstract = "Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.",

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T1 - Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

AU - Taj, Anee

AU - Cui, Chen

AU - Shi, Zhenwei

AU - Huang, Xuebin

AU - Yang, Xiao Hui

PY - 2025/12/7

Y1 - 2025/12/7

N2 - Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.

AB - Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.

UR - https://www.scopus.com/pages/publications/105018197701

U2 - 10.1039/d5qo00926j

DO - 10.1039/d5qo00926j

M3 - Article

AN - SCOPUS:105018197701

SN - 2052-4110

VL - 12

SP - 6401

EP - 6406

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 23

ER -

Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

Abstract

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