TY - JOUR
T1 - Rhodium-catalyzed hydrofunctionalization
T2 - Enantioselective coupling of indolines and 1,3-dienes
AU - Yang, Xiao Hui
AU - Dong, Vy M.
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/2/8
Y1 - 2017/2/8
N2 - We communicate a strategy for the hydrofunctionalization of 1,3-dienes via Rh-hydride catalysis. Conjugated dienes are coupled to nucleophiles to demonstrate the feasibility of novel C-C, C-O, C-S, and C-N bond forming processes. In the presence of a chiral JoSPOphos ligand, hydroamination generates chiral allylic amines with high regio-and enantioselectivity. Tuning both the pKa and steric properties of an acidadditive is critical for enantiocontrol.
AB - We communicate a strategy for the hydrofunctionalization of 1,3-dienes via Rh-hydride catalysis. Conjugated dienes are coupled to nucleophiles to demonstrate the feasibility of novel C-C, C-O, C-S, and C-N bond forming processes. In the presence of a chiral JoSPOphos ligand, hydroamination generates chiral allylic amines with high regio-and enantioselectivity. Tuning both the pKa and steric properties of an acidadditive is critical for enantiocontrol.
UR - https://www.scopus.com/pages/publications/85011966237
U2 - 10.1021/jacs.6b12307
DO - 10.1021/jacs.6b12307
M3 - Article
C2 - 28128936
AN - SCOPUS:85011966237
SN - 0002-7863
VL - 139
SP - 1774
EP - 1777
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 5
ER -