Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia

Rahul T. Kadakia; Da Xie; Hongyu Guo; Bailey Bouley; Meng Yu; Emily L. Que

doi:10.1039/d0dt01182g

Responsive fluorinated nanoemulsions for ¹⁹F magnetic resonance detection of cellular hypoxia

Rahul T. Kadakia, Da Xie, Hongyu Guo, Bailey Bouley, Meng Yu, Emily L. Que^*

^*Corresponding author for this work

Department of Chemistry, University of Texas at Austin

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We report two highly fluorinated Cu-based imaging agents, CuL1 and CuL2, for detecting cellular hypoxia as nanoemulsion formulations. Both complexes retained their initial quenched 19F MR signals due to paramagnetic Cu2+; however, both complexes displayed a large signal increase when the complex was reduced. DLS studies showed that the CuL1 nanoemulsion (NECuL1) had a hydrodiameter of approximately 100 nm and that it was stable for four weeks post-preparation. Hypoxic cells incubated with NECuL1 showed that 40% of the Cu2+ taken up was reduced in low oxygen environments.

Original language	English
Pages (from-to)	16419-16424
Number of pages	6
Journal	Dalton Transactions
Volume	49
Issue number	45
DOIs	https://doi.org/10.1039/d0dt01182g
Publication status	Published - 7 Dec 2020
Externally published	Yes

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title = "Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia",

abstract = "We report two highly fluorinated Cu-based imaging agents, CuL1 and CuL2, for detecting cellular hypoxia as nanoemulsion formulations. Both complexes retained their initial quenched 19F MR signals due to paramagnetic Cu2+; however, both complexes displayed a large signal increase when the complex was reduced. DLS studies showed that the CuL1 nanoemulsion (NECuL1) had a hydrodiameter of approximately 100 nm and that it was stable for four weeks post-preparation. Hypoxic cells incubated with NECuL1 showed that 40% of the Cu2+ taken up was reduced in low oxygen environments.",

author = "Kadakia, {Rahul T.} and Da Xie and Hongyu Guo and Bailey Bouley and Meng Yu and Que, {Emily L.}",

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T1 - Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia

AU - Kadakia, Rahul T.

AU - Xie, Da

AU - Guo, Hongyu

AU - Bouley, Bailey

AU - Yu, Meng

AU - Que, Emily L.

PY - 2020/12/7

Y1 - 2020/12/7

N2 - We report two highly fluorinated Cu-based imaging agents, CuL1 and CuL2, for detecting cellular hypoxia as nanoemulsion formulations. Both complexes retained their initial quenched 19F MR signals due to paramagnetic Cu2+; however, both complexes displayed a large signal increase when the complex was reduced. DLS studies showed that the CuL1 nanoemulsion (NECuL1) had a hydrodiameter of approximately 100 nm and that it was stable for four weeks post-preparation. Hypoxic cells incubated with NECuL1 showed that 40% of the Cu2+ taken up was reduced in low oxygen environments.

AB - We report two highly fluorinated Cu-based imaging agents, CuL1 and CuL2, for detecting cellular hypoxia as nanoemulsion formulations. Both complexes retained their initial quenched 19F MR signals due to paramagnetic Cu2+; however, both complexes displayed a large signal increase when the complex was reduced. DLS studies showed that the CuL1 nanoemulsion (NECuL1) had a hydrodiameter of approximately 100 nm and that it was stable for four weeks post-preparation. Hypoxic cells incubated with NECuL1 showed that 40% of the Cu2+ taken up was reduced in low oxygen environments.

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SN - 1477-9226

VL - 49

SP - 16419

EP - 16424

JO - Dalton Transactions

JF - Dalton Transactions

IS - 45

ER -

Responsive fluorinated nanoemulsions for ¹⁹F magnetic resonance detection of cellular hypoxia

Abstract

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