Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

Yanyan Cui; Jian Yang; Qunfang Zhou; Ping Liang; Yaling Wang; Xueyun Gao; Yongtian Wang

doi:10.1021/acsami.6b16133

Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

Yanyan Cui^*
, Jian Yang
, Qunfang Zhou
, Ping Liang
, Yaling Wang
, Xueyun Gao
, Yongtian Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

Original language	English
Pages (from-to)	5900-5906
Number of pages	7
Journal	ACS Applied Materials and Interfaces
Volume	9
Issue number	7
DOIs	https://doi.org/10.1021/acsami.6b16133
Publication status	Published - 22 Feb 2017
Externally published	Yes

Keywords

X-ray CT imaging
photothermal therapy
protein
renal clearable
silver nanodots

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10.1021/acsami.6b16133

Cite this

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title = "Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy",

abstract = "Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2\% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.",

keywords = "X-ray CT imaging, photothermal therapy, protein, renal clearable, silver nanodots",

author = "Yanyan Cui and Jian Yang and Qunfang Zhou and Ping Liang and Yaling Wang and Xueyun Gao and Yongtian Wang",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

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doi = "10.1021/acsami.6b16133",

language = "English",

volume = "9",

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T1 - Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

AU - Cui, Yanyan

AU - Yang, Jian

AU - Zhou, Qunfang

AU - Liang, Ping

AU - Wang, Yaling

AU - Gao, Xueyun

AU - Wang, Yongtian

PY - 2017/2/22

Y1 - 2017/2/22

N2 - Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

AB - Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

KW - X-ray CT imaging

KW - photothermal therapy

KW - protein

KW - renal clearable

KW - silver nanodots

UR - https://www.scopus.com/pages/publications/85013436828

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DO - 10.1021/acsami.6b16133

M3 - Article

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AN - SCOPUS:85013436828

SN - 1944-8244

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EP - 5906

JO - ACS Applied Materials and Interfaces

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IS - 7

ER -

Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

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Keywords

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