Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells

Bing Jie Xie; Fan Kai Lin; Kaleem Ullah; Lei Peng; Hong Qing; Yu Lin Deng

doi:10.1201/b18418-102

Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells

Bing Jie Xie
, Fan Kai Lin
, Kaleem Ullah
, Lei Peng
, Hong Qing
, Yu Lin Deng^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

As evidence for the roles of methylglyoxal in the development of diabetic neuropathy, oxidative stress and mitochondrial dysfunction play a key role in the mechanism of methylglyoxal-induced cell apoptosis. In this study, the results showed that dopamine can reduce the methylglyoxal-induced the oxidative stress and mitochondrial dysfunction in the SH-SY5Y cells. a-Methyl Tyrosine (MT) can inhibit the synthesis of dopamine, if SH-SY5Y cells was pre-incubated in the (MT), methylglyoxal-induced the oxidative stress and mitochondrial dysfunction was increased. One of PD symptoms is the reduction of the striatal DA content. In addition, the oxidative stress involving lipid peroxidation and mitochondrial dysfunction contributes to the pathogenesis of Parkinson’s Disease (PD). The results give one suggestion that methylglyoxal could enhance the processing the PD.

Original language	English
Title of host publication	Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014
Editors	Mings Wang
Publisher	CRC Press/Balkema
Pages	559-564
Number of pages	6
ISBN (Electronic)	9781138026841
DOIs	https://doi.org/10.1201/b18418-102
Publication status	Published - 2015
Event	Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014 - Kunming, China Duration: 16 Aug 2014 → 17 Aug 2014

Publication series

Name	Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014

Conference

Conference	Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014
Country/Territory	China
City	Kunming
Period	16/08/14 → 17/08/14

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1201/b18418-102

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Xie, B. J., Lin, F. K., Ullah, K., Peng, L., Qing, H., & Deng, Y. L. (2015). Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells. In M. Wang (Ed.), Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014 (pp. 559-564). (Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014). CRC Press/Balkema. https://doi.org/10.1201/b18418-102

Xie, Bing Jie ; Lin, Fan Kai ; Ullah, Kaleem et al. / Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells. Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014. editor / Mings Wang. CRC Press/Balkema, 2015. pp. 559-564 (Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014).

@inproceedings{1e235442284e4193b99e413ac41d403e,

title = "Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells",

abstract = "As evidence for the roles of methylglyoxal in the development of diabetic neuropathy, oxidative stress and mitochondrial dysfunction play a key role in the mechanism of methylglyoxal-induced cell apoptosis. In this study, the results showed that dopamine can reduce the methylglyoxal-induced the oxidative stress and mitochondrial dysfunction in the SH-SY5Y cells. a-Methyl Tyrosine (MT) can inhibit the synthesis of dopamine, if SH-SY5Y cells was pre-incubated in the (MT), methylglyoxal-induced the oxidative stress and mitochondrial dysfunction was increased. One of PD symptoms is the reduction of the striatal DA content. In addition, the oxidative stress involving lipid peroxidation and mitochondrial dysfunction contributes to the pathogenesis of Parkinson{\textquoteright}s Disease (PD). The results give one suggestion that methylglyoxal could enhance the processing the PD.",

author = "Xie, \{Bing Jie\} and Lin, \{Fan Kai\} and Kaleem Ullah and Lei Peng and Hong Qing and Deng, \{Yu Lin\}",

note = "Publisher Copyright: {\textcopyright} 2015 Taylor \& Francis Group, London.; Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014 ; Conference date: 16-08-2014 Through 17-08-2014",

year = "2015",

doi = "10.1201/b18418-102",

language = "English",

series = "Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014",

publisher = "CRC Press/Balkema",

pages = "559--564",

editor = "Mings Wang",

booktitle = "Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014",

}

Xie, BJ, Lin, FK, Ullah, K, Peng, L, Qing, H & Deng, YL 2015, Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells. in M Wang (ed.), Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014. Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014, CRC Press/Balkema, pp. 559-564, Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014, Kunming, China, 16/08/14. https://doi.org/10.1201/b18418-102

Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells. / Xie, Bing Jie; Lin, Fan Kai; Ullah, Kaleem et al.
Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014. ed. / Mings Wang. CRC Press/Balkema, 2015. p. 559-564 (Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells

AU - Xie, Bing Jie

AU - Lin, Fan Kai

AU - Ullah, Kaleem

AU - Peng, Lei

AU - Qing, Hong

AU - Deng, Yu Lin

PY - 2015

Y1 - 2015

N2 - As evidence for the roles of methylglyoxal in the development of diabetic neuropathy, oxidative stress and mitochondrial dysfunction play a key role in the mechanism of methylglyoxal-induced cell apoptosis. In this study, the results showed that dopamine can reduce the methylglyoxal-induced the oxidative stress and mitochondrial dysfunction in the SH-SY5Y cells. a-Methyl Tyrosine (MT) can inhibit the synthesis of dopamine, if SH-SY5Y cells was pre-incubated in the (MT), methylglyoxal-induced the oxidative stress and mitochondrial dysfunction was increased. One of PD symptoms is the reduction of the striatal DA content. In addition, the oxidative stress involving lipid peroxidation and mitochondrial dysfunction contributes to the pathogenesis of Parkinson’s Disease (PD). The results give one suggestion that methylglyoxal could enhance the processing the PD.

AB - As evidence for the roles of methylglyoxal in the development of diabetic neuropathy, oxidative stress and mitochondrial dysfunction play a key role in the mechanism of methylglyoxal-induced cell apoptosis. In this study, the results showed that dopamine can reduce the methylglyoxal-induced the oxidative stress and mitochondrial dysfunction in the SH-SY5Y cells. a-Methyl Tyrosine (MT) can inhibit the synthesis of dopamine, if SH-SY5Y cells was pre-incubated in the (MT), methylglyoxal-induced the oxidative stress and mitochondrial dysfunction was increased. One of PD symptoms is the reduction of the striatal DA content. In addition, the oxidative stress involving lipid peroxidation and mitochondrial dysfunction contributes to the pathogenesis of Parkinson’s Disease (PD). The results give one suggestion that methylglyoxal could enhance the processing the PD.

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AN - SCOPUS:84940749000

T3 - Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014

SP - 559

EP - 564

BT - Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014

A2 - Wang, Mings

PB - CRC Press/Balkema

T2 - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014

Y2 - 16 August 2014 through 17 August 2014

ER -

Xie BJ, Lin FK, Ullah K, Peng L, Qing H, Deng YL. Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells. In Wang M, editor, Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014. CRC Press/Balkema. 2015. p. 559-564. (Medicine Sciences and Bioengineering - Proceedings of the 2014 International Conference on Medicine Sciences and Bioengineering, ICMSB 2014). doi: 10.1201/b18418-102

Reduction of dopamine increases methylglyoxal-induced mitochondrial dysfunction in SH-SY5Y cells

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