Red emissive fluorescent probe for the rapid detection of selenocysteine

Panpan Zhang; Ying Ding; Weimin Liu; Guangle Niu; Hongyan Zhang; Jiechao Ge; Jiasheng Wu; Yanqing Li; Pengfei Wang

doi:10.1016/j.snb.2018.02.185

Red emissive fluorescent probe for the rapid detection of selenocysteine

Panpan Zhang, Ying Ding, Weimin Liu^*, Guangle Niu, Hongyan Zhang, Jiechao Ge, Jiasheng Wu, Yanqing Li, Pengfei Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A novel fluorescent probe O-hNRSel based on tetralin-xanthene fused dye O-hNR was designed and synthesized by introducing 2,4-dinitrobenzenesulfonate functionality. This probe is able to detect selenocysteine (Sec) with rapid response time (2 min) and a large fluorescence enhancement at 624 nm (124-fold). O-hNRSel exhibited selective response to Sec over many other analy and high sensitivity with the detection limit as low as 17 nM. Furthermore, O-hNRSel has been used for fluorescent imaging of Sec in living cells with good biocompatibility.

Original language	English
Pages (from-to)	234-239
Number of pages	6
Journal	Sensors and Actuators, B: Chemical
Volume	264
DOIs	https://doi.org/10.1016/j.snb.2018.02.185
Publication status	Published - 1 Jul 2018
Externally published	Yes

Keywords

Cell imaging
Fluorescent probe
Selenocysteine
Xanthene dyes

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10.1016/j.snb.2018.02.185

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title = "Red emissive fluorescent probe for the rapid detection of selenocysteine",

abstract = "A novel fluorescent probe O-hNRSel based on tetralin-xanthene fused dye O-hNR was designed and synthesized by introducing 2,4-dinitrobenzenesulfonate functionality. This probe is able to detect selenocysteine (Sec) with rapid response time (2 min) and a large fluorescence enhancement at 624 nm (124-fold). O-hNRSel exhibited selective response to Sec over many other analy and high sensitivity with the detection limit as low as 17 nM. Furthermore, O-hNRSel has been used for fluorescent imaging of Sec in living cells with good biocompatibility.",

keywords = "Cell imaging, Fluorescent probe, Selenocysteine, Xanthene dyes",

author = "Panpan Zhang and Ying Ding and Weimin Liu and Guangle Niu and Hongyan Zhang and Jiechao Ge and Jiasheng Wu and Yanqing Li and Pengfei Wang",

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year = "2018",

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doi = "10.1016/j.snb.2018.02.185",

language = "English",

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TY - JOUR

T1 - Red emissive fluorescent probe for the rapid detection of selenocysteine

AU - Zhang, Panpan

AU - Ding, Ying

AU - Liu, Weimin

AU - Niu, Guangle

AU - Zhang, Hongyan

AU - Ge, Jiechao

AU - Wu, Jiasheng

AU - Li, Yanqing

AU - Wang, Pengfei

PY - 2018/7/1

Y1 - 2018/7/1

N2 - A novel fluorescent probe O-hNRSel based on tetralin-xanthene fused dye O-hNR was designed and synthesized by introducing 2,4-dinitrobenzenesulfonate functionality. This probe is able to detect selenocysteine (Sec) with rapid response time (2 min) and a large fluorescence enhancement at 624 nm (124-fold). O-hNRSel exhibited selective response to Sec over many other analy and high sensitivity with the detection limit as low as 17 nM. Furthermore, O-hNRSel has been used for fluorescent imaging of Sec in living cells with good biocompatibility.

AB - A novel fluorescent probe O-hNRSel based on tetralin-xanthene fused dye O-hNR was designed and synthesized by introducing 2,4-dinitrobenzenesulfonate functionality. This probe is able to detect selenocysteine (Sec) with rapid response time (2 min) and a large fluorescence enhancement at 624 nm (124-fold). O-hNRSel exhibited selective response to Sec over many other analy and high sensitivity with the detection limit as low as 17 nM. Furthermore, O-hNRSel has been used for fluorescent imaging of Sec in living cells with good biocompatibility.

KW - Cell imaging

KW - Fluorescent probe

KW - Selenocysteine

KW - Xanthene dyes

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U2 - 10.1016/j.snb.2018.02.185

DO - 10.1016/j.snb.2018.02.185

M3 - Article

AN - SCOPUS:85042918000

SN - 0925-4005

VL - 264

SP - 234

EP - 239

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

Red emissive fluorescent probe for the rapid detection of selenocysteine

Abstract

Keywords

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