Abstract
Novel enzymatic microsystems have strong prospects in chemical and biological analysis due to their low consumption of reagents, fast analysis time, easy manipulation and satisfactory portability. Nanomaterials (NMs)provide a favorable platform for integrating enzymes into microsystems with enhanced selectivity and sensitivity. Various NM-enzyme immobilization strategies applied in the fabrication of capillary-based and chip-based enzymatic microsystems are summarized in this manuscript. We focus on highlighting the advantages of employing NM-based enzymatic microsystems for enantioseparation, inhibitor screening, bioreaction and biosensing. Innovative nanocomposites and NM-functionalized monoliths used to construct multienzymatic microsystems are also illustrated. The general development trend identified in this review indicates that the application of NMs has significantly improved enzymatic microsystem performance.
| Original language | English |
|---|---|
| Pages (from-to) | 31-47 |
| Number of pages | 17 |
| Journal | Analytica Chimica Acta |
| Volume | 1067 |
| DOIs | |
| Publication status | Published - 27 Aug 2019 |
| Externally published | Yes |
Keywords
- Bioreaction
- Biosensor
- Capillary monolith
- Enzymatic microsystem
- Microchip
- Nanomaterial
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