TY - GEN
T1 - Quantitative analysis of lymphocytes morphology and motion in intravital microscopic images
AU - Huang, Yali
AU - Liu, Zhiwen
AU - Shi, Yonggang
AU - Li, Ning
AU - An, Xing
AU - Gou, Xiaoming
PY - 2013
Y1 - 2013
N2 - Studying the morphology and interior movement of lymphocytes in intravital microscopic images is essential to understanding and treating various biological processes and pathological situations. A method combing features of shape, deformation, and intracellular motion for quantitatively characterizing the dynamic behavior of a single lymphocyte is proposed in this paper. The method is tested on a set of image sequences of lymphocytes obtained from the peripheral blood of mice undergoing skin transplantation using a phase contrast microscope. Experimental results coincide with the clinical observation and pathological analysis, demonstrating that the extracted cell morphology and motion features can provide new insights into the relationship between the dynamic behavior of lymphocytes and the occurrence of graft rejection.
AB - Studying the morphology and interior movement of lymphocytes in intravital microscopic images is essential to understanding and treating various biological processes and pathological situations. A method combing features of shape, deformation, and intracellular motion for quantitatively characterizing the dynamic behavior of a single lymphocyte is proposed in this paper. The method is tested on a set of image sequences of lymphocytes obtained from the peripheral blood of mice undergoing skin transplantation using a phase contrast microscope. Experimental results coincide with the clinical observation and pathological analysis, demonstrating that the extracted cell morphology and motion features can provide new insights into the relationship between the dynamic behavior of lymphocytes and the occurrence of graft rejection.
UR - http://www.scopus.com/inward/record.url?scp=84886462518&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2013.6610343
DO - 10.1109/EMBC.2013.6610343
M3 - Conference contribution
C2 - 24110530
AN - SCOPUS:84886462518
SN - 9781457702167
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 3686
EP - 3689
BT - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
T2 - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Y2 - 3 July 2013 through 7 July 2013
ER -