TY - JOUR
T1 - PubAngioGen
T2 - A database and knowledge for angiogenesis and related diseases
AU - Li, Peng
AU - Liu, Yongrui
AU - Wang, Huan
AU - He, Yuan
AU - Wang, Xue
AU - He, Yundong
AU - Lv, Fang
AU - Chen, Huaqing
AU - Pang, Xiufeng
AU - Liu, Mingyao
AU - Shi, Tieliu
AU - Yi, Zhengfang
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2015/1/28
Y1 - 2015/1/28
N2 - Angiogenesis is the process of generating new blood vessels based on existing ones, which is involved in many diseases including cancers, cardiovascular diseases and diabetes mellitus. Recently, great efforts have been made to explore the mechanisms of angiogenesis in various diseases and many angiogenic factors have been discovered as therapeutic targets in anti- or pro-angiogenic drug development. However, the resulted information is sparsely distributed and no systematical summarization has been made. In order to integrate these related results and facilitate the researches for the community, we conducted manual text-mining from published literature and built a database named as PubAngio-Gen (http://www.megabionet.org/aspd/). Our online application displays a comprehensive network for exploring the connection between angiogenesis and diseases at multilevels including protein-protein interaction, drug-target, disease-gene and signaling pathways among various cells and animal models recorded through text-mining. To enlarge the scope of the PubAngioGen application, our database also links to other common resources including STRING, DrugBank and OMIM databases, which will facilitate understanding the underlying molecular mechanisms of angiogenesis and drug development in clinical therapy.
AB - Angiogenesis is the process of generating new blood vessels based on existing ones, which is involved in many diseases including cancers, cardiovascular diseases and diabetes mellitus. Recently, great efforts have been made to explore the mechanisms of angiogenesis in various diseases and many angiogenic factors have been discovered as therapeutic targets in anti- or pro-angiogenic drug development. However, the resulted information is sparsely distributed and no systematical summarization has been made. In order to integrate these related results and facilitate the researches for the community, we conducted manual text-mining from published literature and built a database named as PubAngio-Gen (http://www.megabionet.org/aspd/). Our online application displays a comprehensive network for exploring the connection between angiogenesis and diseases at multilevels including protein-protein interaction, drug-target, disease-gene and signaling pathways among various cells and animal models recorded through text-mining. To enlarge the scope of the PubAngioGen application, our database also links to other common resources including STRING, DrugBank and OMIM databases, which will facilitate understanding the underlying molecular mechanisms of angiogenesis and drug development in clinical therapy.
UR - http://www.scopus.com/inward/record.url?scp=84941094166&partnerID=8YFLogxK
U2 - 10.1093/nar/gku1139
DO - 10.1093/nar/gku1139
M3 - Article
C2 - 25392416
AN - SCOPUS:84941094166
SN - 0305-1048
VL - 43
SP - D963-D967
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -
