TY - JOUR
T1 - Primary aldosteronism and obstructive sleep apnea
T2 - A meta-analysis of prevalence and metabolic characteristics
AU - Zhang, Rui
AU - Cai, Xiaoling
AU - lin, Chu
AU - Yang, Wenjia
AU - Lv, Fang
AU - Han, Xueyao
AU - Ji, Linong
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2024/2
Y1 - 2024/2
N2 - Background: Primary aldosteronism (PA) and obstructive sleep apnea (OSA) are both causes for resistant hypertension and contribute to adverse cardiovascular outcome. However, the association of these two disorders remains to be investigated. We conducted this meta-analysis to estimate the prevalence and metabolic characteristics of the coexistence of PA and OSA. Methods: The databases of MEDLINE, EMBASE and Cochrane Reviews were searched for studies investigating the prevalence or clinical characteristics of PA and OSA until Jan 2023. Single proportions of PA and OSA were meta-analyzed for pooled prevalence and 95% confidence intervals (CIs). Odds ratios (ORs) and 95% CIs were calculated for the comparison of the prevalence. Mean differences (MDs) and 95% CIs were calculated for comparisons of the characteristics between patients with both OSA and PA and control groups. Results: A total of 16 studies were included. The pooled prevalence of PA was 27% (95% CI = 24–29%) in all patients with OSA (n = 3498). The prevalence of PA in patients with OSA was significantly higher than that in the patients without OSA (OR = 2.03, 95% CI = 1.30, 3.16, p = 0.002). The pooled prevalence (95% CI) of OSA was 46% (39–54%) in patients with PA (n = 2335). Compared with the hypertensive patients without PA, the prevalence of OSA in the patients with PA was significantly higher (OR = 2.01, 95% CI = 1.37, 2.95, p < 0.001). Compared with the patients of control groups, the patients with both PA and OSA had higher blood pressure and body mass index (BMI). Conclusion: Screening for the coexistence of PA and OSA was warranted.
AB - Background: Primary aldosteronism (PA) and obstructive sleep apnea (OSA) are both causes for resistant hypertension and contribute to adverse cardiovascular outcome. However, the association of these two disorders remains to be investigated. We conducted this meta-analysis to estimate the prevalence and metabolic characteristics of the coexistence of PA and OSA. Methods: The databases of MEDLINE, EMBASE and Cochrane Reviews were searched for studies investigating the prevalence or clinical characteristics of PA and OSA until Jan 2023. Single proportions of PA and OSA were meta-analyzed for pooled prevalence and 95% confidence intervals (CIs). Odds ratios (ORs) and 95% CIs were calculated for the comparison of the prevalence. Mean differences (MDs) and 95% CIs were calculated for comparisons of the characteristics between patients with both OSA and PA and control groups. Results: A total of 16 studies were included. The pooled prevalence of PA was 27% (95% CI = 24–29%) in all patients with OSA (n = 3498). The prevalence of PA in patients with OSA was significantly higher than that in the patients without OSA (OR = 2.03, 95% CI = 1.30, 3.16, p = 0.002). The pooled prevalence (95% CI) of OSA was 46% (39–54%) in patients with PA (n = 2335). Compared with the hypertensive patients without PA, the prevalence of OSA in the patients with PA was significantly higher (OR = 2.01, 95% CI = 1.37, 2.95, p < 0.001). Compared with the patients of control groups, the patients with both PA and OSA had higher blood pressure and body mass index (BMI). Conclusion: Screening for the coexistence of PA and OSA was warranted.
KW - Coexistence
KW - Metabolic characteristics
KW - Obstructive sleep apnea
KW - Prevalence
KW - Primary aldosteronism
UR - http://www.scopus.com/inward/record.url?scp=85180600573&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2023.12.007
DO - 10.1016/j.sleep.2023.12.007
M3 - Article
C2 - 38142557
AN - SCOPUS:85180600573
SN - 1389-9457
VL - 114
SP - 8
EP - 14
JO - Sleep Medicine
JF - Sleep Medicine
ER -