Preparation of (R)-N-methylsalsolinol via reversed-phase high- performance liquid chromatography using β-cyclodextrin as a mobile-phase additive

Chiyoko Minami; Yulin Deng; Fumi Urano; Toyo Kaiya; Kohfuku Kohda; Masao Kawai; Makoto Naoi

doi:10.1016/S0378-4347(97)00374-5

Preparation of (R)-N-methylsalsolinol via reversed-phase high- performance liquid chromatography using β-cyclodextrin as a mobile-phase additive

Chiyoko Minami
, Yulin Deng
, Fumi Urano
, Toyo Kaiya
, Kohfuku Kohda
, Masao Kawai
, Makoto Naoi^*

^*Corresponding author for this work

Nagoya Institute of Technology
Nagoya City University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A new preparation method was devised using β-cyclodextrin as a mobile- phase additive in a reversed-phase high-performance liquid chromatography system. Preparative separation of the biologically active (R)-enantiomer was achieved from racemic N-methylsalsolinol. β-Cyclodextrin was removed completely in good yield by acid extraction and solid-phase extraction. By a slight modification, this method will be applicable to the isolation of various types of biologically important enantiomers.

Original language	English
Pages (from-to)	245-248
Number of pages	4
Journal	Journal of Chromatography B, Biomedical Applications
Volume	702
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-4347(97)00374-5
Publication status	Published - 21 Nov 1997
Externally published	Yes

Keywords

(R)-N-Methylsalsolinol

Access to Document

10.1016/S0378-4347(97)00374-5

Cite this

@article{0643a60d353c4c4b9a18086f90f4959b,

title = "Preparation of (R)-N-methylsalsolinol via reversed-phase high- performance liquid chromatography using β-cyclodextrin as a mobile-phase additive",

abstract = "A new preparation method was devised using β-cyclodextrin as a mobile- phase additive in a reversed-phase high-performance liquid chromatography system. Preparative separation of the biologically active (R)-enantiomer was achieved from racemic N-methylsalsolinol. β-Cyclodextrin was removed completely in good yield by acid extraction and solid-phase extraction. By a slight modification, this method will be applicable to the isolation of various types of biologically important enantiomers.",

keywords = "(R)-N-Methylsalsolinol",

author = "Chiyoko Minami and Yulin Deng and Fumi Urano and Toyo Kaiya and Kohfuku Kohda and Masao Kawai and Makoto Naoi",

year = "1997",

month = nov,

day = "21",

doi = "10.1016/S0378-4347(97)00374-5",

language = "English",

volume = "702",

pages = "245--248",

journal = "Journal of Chromatography B, Biomedical Applications",

issn = "1572-6495",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Preparation of (R)-N-methylsalsolinol via reversed-phase high- performance liquid chromatography using β-cyclodextrin as a mobile-phase additive

AU - Minami, Chiyoko

AU - Deng, Yulin

AU - Urano, Fumi

AU - Kaiya, Toyo

AU - Kohda, Kohfuku

AU - Kawai, Masao

AU - Naoi, Makoto

PY - 1997/11/21

Y1 - 1997/11/21

N2 - A new preparation method was devised using β-cyclodextrin as a mobile- phase additive in a reversed-phase high-performance liquid chromatography system. Preparative separation of the biologically active (R)-enantiomer was achieved from racemic N-methylsalsolinol. β-Cyclodextrin was removed completely in good yield by acid extraction and solid-phase extraction. By a slight modification, this method will be applicable to the isolation of various types of biologically important enantiomers.

AB - A new preparation method was devised using β-cyclodextrin as a mobile- phase additive in a reversed-phase high-performance liquid chromatography system. Preparative separation of the biologically active (R)-enantiomer was achieved from racemic N-methylsalsolinol. β-Cyclodextrin was removed completely in good yield by acid extraction and solid-phase extraction. By a slight modification, this method will be applicable to the isolation of various types of biologically important enantiomers.

KW - (R)-N-Methylsalsolinol

UR - https://www.scopus.com/pages/publications/0031582879

U2 - 10.1016/S0378-4347(97)00374-5

DO - 10.1016/S0378-4347(97)00374-5

M3 - Article

C2 - 9449579

AN - SCOPUS:0031582879

SN - 1572-6495

VL - 702

SP - 245

EP - 248

JO - Journal of Chromatography B, Biomedical Applications

JF - Journal of Chromatography B, Biomedical Applications

IS - 1-2

ER -

Preparation of (R)-N-methylsalsolinol via reversed-phase high- performance liquid chromatography using β-cyclodextrin as a mobile-phase additive

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this