Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis

Min Ma; Guo Wei Yao; Jian Hua Liang

Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis

Min Ma^*
, Guo Wei Yao
, Jian Hua Liang

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 % and 98.0 %, respectively.

Original language	English
Pages (from-to)	238-240
Number of pages	3
Journal	Xiandai Huagong/Modern Chemical Industry
Volume	26
Issue number	SUPPL.
Publication status	Published - Jul 2006

Keywords

9-deoxo-9a-aza-9a-homoerythromycin A
Azithromycin
Erythromycin A oxime
One spot synthesis

Cite this

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title = "Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis",

abstract = "One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 \% and 98.0 \%, respectively.",

keywords = "9-deoxo-9a-aza-9a-homoerythromycin A, Azithromycin, Erythromycin A oxime, One spot synthesis",

author = "Min Ma and Yao, \{Guo Wei\} and Liang, \{Jian Hua\}",

year = "2006",

month = jul,

language = "English",

volume = "26",

pages = "238--240",

journal = "Xiandai Huagong/Modern Chemical Industry",

issn = "0253-4320",

publisher = "China National Chemical Information Center",

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TY - JOUR

T1 - Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis

AU - Ma, Min

AU - Yao, Guo Wei

AU - Liang, Jian Hua

PY - 2006/7

Y1 - 2006/7

N2 - One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 % and 98.0 %, respectively.

AB - One-pot synthesis is applied for the first time to prepare 9-deoxo-9a-aza-9a-homoerythromycin A (AZA). Sodium borohydride is added in situ while erythromycin 6, 9-imino ether is formed by Beckmann rearrangement from erythromycin A oxime in methanol. The results show the purity and yield of products are 90.5 % and 98.0 %, respectively.

KW - 9-deoxo-9a-aza-9a-homoerythromycin A

KW - Azithromycin

KW - Erythromycin A oxime

KW - One spot synthesis

UR - https://www.scopus.com/pages/publications/33748689060

M3 - Article

AN - SCOPUS:33748689060

SN - 0253-4320

VL - 26

SP - 238

EP - 240

JO - Xiandai Huagong/Modern Chemical Industry

JF - Xiandai Huagong/Modern Chemical Industry

IS - SUPPL.

ER -

Preparation of 9-deoxo-9a-aza-9a-homoerythromycin A by one-pot synthesis

Abstract

Keywords

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