Preparation and application of poly(vinyl alcohol)-chitosan interpenetrating polymer sponge

Poly(vinyl alcohol)-chitosan interpenetrating polymer network was synthesized in acetic acid solution with polyvinyl alcohol and chitosan as raw materials, glutaraldehyde as crosslinker, sodium hyaluronate and gelatin as additives. After freezing dry, the interpenetrating polymer sponge was prepared. The molecular structure of the sponge was confirmed by FT-IR, and the surface morphologies were examined by SEM. The factors influencing the swelling properties of the sponge were studied. It is found that the optimum reaction condition is that m_PVA-1788:m_CTS=6:1, m_{Sodium,hyaluronate}:m_CTS=0.4:1, m_{glutaraldehyde}:m_CTS=0.283:1, m_GEL:m_CTS=1:1, C_PVA-1788=0.97 mol/L. The pores superabsorbent sponge prepared through these conditions can absorb over 25 g/g distilled water. The hemostatic properties of the sponge were studied through the hemostatic models of ear artery of rabbits. The results show that the hemostatic ratio is 100% and the using of the sponge reduces the hemostatic time and the loss of blood. All of these show that the hemostatic properties of the sponge are ideal.