TY - JOUR
T1 - Prenylation
T2 - A Critical Step for Biomanufacturing of Prenylated Aromatic Natural Products
AU - An, Ting
AU - Feng, Xudong
AU - Li, Chun
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/2/8
Y1 - 2023/2/8
N2 - Prenylated aromatic natural products (PANPs) have received much attention due to their biomedical benefits for human health. The prenylation of aromatic natural products (ANPs), which is mainly catalyzed by aromatic prenyltransferases (aPTs), contributes significantly to their structural and functional diversity by providing higher lipophilicity and enhanced bioactivity. aPTs are widely distributed in bacteria, fungi, animals, and plants and play a key role in the regiospecific prenylation of ANPs. Recent studies have greatly advanced our understanding of the characteristics and application of aPTs. In this review, we comment on research progress regarding sources, evolutionary relationships, structural features, reaction mechanism, engineering modification, and application of aPTs. Particular emphasis is also placed on recent advances, challenges, and prospects about applications of aPTs in microbial cell factories for producing PANPs. Generally, this review could provide guidance for using aPTs as robust biocatalytic tools to produce various PANPs with high efficiency.
AB - Prenylated aromatic natural products (PANPs) have received much attention due to their biomedical benefits for human health. The prenylation of aromatic natural products (ANPs), which is mainly catalyzed by aromatic prenyltransferases (aPTs), contributes significantly to their structural and functional diversity by providing higher lipophilicity and enhanced bioactivity. aPTs are widely distributed in bacteria, fungi, animals, and plants and play a key role in the regiospecific prenylation of ANPs. Recent studies have greatly advanced our understanding of the characteristics and application of aPTs. In this review, we comment on research progress regarding sources, evolutionary relationships, structural features, reaction mechanism, engineering modification, and application of aPTs. Particular emphasis is also placed on recent advances, challenges, and prospects about applications of aPTs in microbial cell factories for producing PANPs. Generally, this review could provide guidance for using aPTs as robust biocatalytic tools to produce various PANPs with high efficiency.
KW - aromatic prenyltransferases
KW - biocatalysis
KW - biomanufacturing
KW - microbial cell factories
KW - prenylated aromatic natural products
UR - http://www.scopus.com/inward/record.url?scp=85147209422&partnerID=8YFLogxK
U2 - 10.1021/acs.jafc.2c07287
DO - 10.1021/acs.jafc.2c07287
M3 - Review article
C2 - 36716399
AN - SCOPUS:85147209422
SN - 0021-8561
VL - 71
SP - 2211
EP - 2233
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 5
ER -
