Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy

Shaowei Wang; Wenbo Wu; Purnima Manghnani; Shidang Xu; Yuanbo Wang; Chi Ching Goh; Lai Guan Ng; Bin Liu

doi:10.1021/acsnano.8b08398

Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy

Shaowei Wang, Wenbo Wu, Purnima Manghnani, Shidang Xu, Yuanbo Wang, Chi Ching Goh, Lai Guan Ng, Bin Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

193 Citations (Scopus)

Abstract

Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen ( ¹ O ₂ ) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high ¹ O ₂ generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.

Original language	English
Pages (from-to)	3095-3105
Number of pages	11
Journal	ACS Nano
Volume	13
Issue number	3
DOIs	https://doi.org/10.1021/acsnano.8b08398
Publication status	Published - 26 Mar 2019
Externally published	Yes

Keywords

aggregation-induced emission
conjugated polymer
photodynamic therapy
photosensitizer
two-photon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsnano.8b08398

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title = "Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy",

abstract = " Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen ( 1 O 2 ) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1 O 2 generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.",

keywords = "aggregation-induced emission, conjugated polymer, photodynamic therapy, photosensitizer, two-photon",

author = "Shaowei Wang and Wenbo Wu and Purnima Manghnani and Shidang Xu and Yuanbo Wang and Goh, {Chi Ching} and Ng, {Lai Guan} and Bin Liu",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = mar,

day = "26",

doi = "10.1021/acsnano.8b08398",

language = "English",

volume = "13",

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T1 - Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy

AU - Wang, Shaowei

AU - Wu, Wenbo

AU - Manghnani, Purnima

AU - Xu, Shidang

AU - Wang, Yuanbo

AU - Goh, Chi Ching

AU - Ng, Lai Guan

AU - Liu, Bin

PY - 2019/3/26

Y1 - 2019/3/26

N2 - Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen ( 1 O 2 ) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1 O 2 generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.

AB - Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen ( 1 O 2 ) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1 O 2 generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.

KW - aggregation-induced emission

KW - conjugated polymer

KW - photodynamic therapy

KW - photosensitizer

KW - two-photon

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JO - ACS Nano

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IS - 3

ER -

Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy

Abstract

Keywords

UN SDGs

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