TY - JOUR
T1 - Polymer nanoparticles with high photothermal conversion efficiency as robust photoacoustic and thermal theranostics
AU - Guo, Liang
AU - Liu, Weimin
AU - Niu, Guangle
AU - Zhang, Panpan
AU - Zheng, Xiuli
AU - Jia, Qingyan
AU - Zhang, Hongyan
AU - Ge, Jiechao
AU - Wang, Pengfei
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2017
Y1 - 2017
N2 - Synthesis of photothermal agents with absorption in the near-infrared (NIR) region and featuring excellent photostability, high photothermal conversion efficiency, and good biocompatibility is necessary for the application of photothermal therapy (PTT). In this work, a low band gap thiophene-benzene-diketopyrrolopyrrole (TBD)-based polymer was synthesized and used to fabricate TBD polymer nanoparticles (TBDPNPs) through a one-step nanoprecipitation method. The obtained near-infrared-absorbing TBDPNPs presented good water dispersibility, high photothermal stability, and low toxicity. Significantly, the TBDPNPs exhibited an ultrahigh photothermal conversion efficiency of approximately 68.1% under 671 nm laser irradiation. In addition, photoacoustic (PA) imaging, with high spatial resolution and deep tissue penetration, showed that the TBDPNPs targeted tumor sites through the enhanced permeability and retention effect. Therefore, the robust TBDPNPs with a photothermal conversion efficiency of 68.1% can serve as an excellent therapeutic agent for PA-imaging-guided PTT.
AB - Synthesis of photothermal agents with absorption in the near-infrared (NIR) region and featuring excellent photostability, high photothermal conversion efficiency, and good biocompatibility is necessary for the application of photothermal therapy (PTT). In this work, a low band gap thiophene-benzene-diketopyrrolopyrrole (TBD)-based polymer was synthesized and used to fabricate TBD polymer nanoparticles (TBDPNPs) through a one-step nanoprecipitation method. The obtained near-infrared-absorbing TBDPNPs presented good water dispersibility, high photothermal stability, and low toxicity. Significantly, the TBDPNPs exhibited an ultrahigh photothermal conversion efficiency of approximately 68.1% under 671 nm laser irradiation. In addition, photoacoustic (PA) imaging, with high spatial resolution and deep tissue penetration, showed that the TBDPNPs targeted tumor sites through the enhanced permeability and retention effect. Therefore, the robust TBDPNPs with a photothermal conversion efficiency of 68.1% can serve as an excellent therapeutic agent for PA-imaging-guided PTT.
UR - http://www.scopus.com/inward/record.url?scp=85017563483&partnerID=8YFLogxK
U2 - 10.1039/c7tb00498b
DO - 10.1039/c7tb00498b
M3 - Article
C2 - 32264170
AN - SCOPUS:85017563483
SN - 2050-7518
VL - 5
SP - 2832
EP - 2839
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 15
ER -