Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects

Shunhao Wang; Andreas Riedinger; Hongbo Li; Changhui Fu; Huiyu Liu; Linlin Li; Tianlong Liu; Longfei Tan; Markus J. Barthel; Giammarino Pugliese; Francesco De Donato; Marco Scotto D'Abbusco; Xianwei Meng; Liberato Manna; Huan Meng; Teresa Pellegrino

doi:10.1021/nn506687t

Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects

Shunhao Wang, Andreas Riedinger, Hongbo Li, Changhui Fu, Huiyu Liu^*, Linlin Li, Tianlong Liu, Longfei Tan, Markus J. Barthel, Giammarino Pugliese, Francesco De Donato, Marco Scotto D'Abbusco, Xianwei Meng, Liberato Manna, Huan Meng, Teresa Pellegrino

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

562 Citations (Scopus)

Abstract

Recently, plasmonic copper sulfide (Cu_2-xS) nanocrystals (NCs) have attracted much attention as materials for photothermal therapy (PTT). Previous reports have correlated photoinduced cell death to the photothermal heat mechanism of these NCs, and no evidence of their photodynamic properties has been reported yet. Herein we have prepared physiologically stable near-infrared (NIR) plasmonic copper sulfide NCs and analyzed their photothermal and photodynamic properties, including therapeutic potential in cultured melanoma cells and a murine melanoma model. Interestingly, we observe that, besides a high PTT efficacy, these copper sulfide NCs additionally possess intrinsic NIR induced photodynamic activity, whereupon they generate high levels of reactive oxygen species. Furthermore, in vitro and in vivo acute toxic responses of copper sulfide NCs were also elicited. This study highlights a mechanism of NIR light induced cancer therapy, which could pave the way toward more effective nanotherapeutics.

Original language	English
Pages (from-to)	1788-1800
Number of pages	13
Journal	ACS Nano
Volume	9
Issue number	2
DOIs	https://doi.org/10.1021/nn506687t
Publication status	Published - 24 Feb 2015
Externally published	Yes

Keywords

copper sulfide nanocrystals
near-infrared light
photodynamic therapy
photothermal therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/nn506687t

Cite this

Wang, S., Riedinger, A., Li, H., Fu, C., Liu, H., Li, L., Liu, T., Tan, L., Barthel, M. J., Pugliese, G., De Donato, F., Scotto D'Abbusco, M., Meng, X., Manna, L., Meng, H., & Pellegrino, T. (2015). Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects. ACS Nano, 9(2), 1788-1800. https://doi.org/10.1021/nn506687t

@article{85e3aedd2d0d46f2bfbbd3ebfd3483d3,

title = "Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects",

abstract = "Recently, plasmonic copper sulfide (Cu2-xS) nanocrystals (NCs) have attracted much attention as materials for photothermal therapy (PTT). Previous reports have correlated photoinduced cell death to the photothermal heat mechanism of these NCs, and no evidence of their photodynamic properties has been reported yet. Herein we have prepared physiologically stable near-infrared (NIR) plasmonic copper sulfide NCs and analyzed their photothermal and photodynamic properties, including therapeutic potential in cultured melanoma cells and a murine melanoma model. Interestingly, we observe that, besides a high PTT efficacy, these copper sulfide NCs additionally possess intrinsic NIR induced photodynamic activity, whereupon they generate high levels of reactive oxygen species. Furthermore, in vitro and in vivo acute toxic responses of copper sulfide NCs were also elicited. This study highlights a mechanism of NIR light induced cancer therapy, which could pave the way toward more effective nanotherapeutics.",

keywords = "copper sulfide nanocrystals, near-infrared light, photodynamic therapy, photothermal therapy",

author = "Shunhao Wang and Andreas Riedinger and Hongbo Li and Changhui Fu and Huiyu Liu and Linlin Li and Tianlong Liu and Longfei Tan and Barthel, {Markus J.} and Giammarino Pugliese and {De Donato}, Francesco and {Scotto D'Abbusco}, Marco and Xianwei Meng and Liberato Manna and Huan Meng and Teresa Pellegrino",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = feb,

day = "24",

doi = "10.1021/nn506687t",

language = "English",

volume = "9",

pages = "1788--1800",

journal = "ACS Nano",

issn = "1936-0851",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects

AU - Wang, Shunhao

AU - Riedinger, Andreas

AU - Li, Hongbo

AU - Fu, Changhui

AU - Liu, Huiyu

AU - Li, Linlin

AU - Liu, Tianlong

AU - Tan, Longfei

AU - Barthel, Markus J.

AU - Pugliese, Giammarino

AU - De Donato, Francesco

AU - Scotto D'Abbusco, Marco

AU - Meng, Xianwei

AU - Manna, Liberato

AU - Meng, Huan

AU - Pellegrino, Teresa

PY - 2015/2/24

Y1 - 2015/2/24

N2 - Recently, plasmonic copper sulfide (Cu2-xS) nanocrystals (NCs) have attracted much attention as materials for photothermal therapy (PTT). Previous reports have correlated photoinduced cell death to the photothermal heat mechanism of these NCs, and no evidence of their photodynamic properties has been reported yet. Herein we have prepared physiologically stable near-infrared (NIR) plasmonic copper sulfide NCs and analyzed their photothermal and photodynamic properties, including therapeutic potential in cultured melanoma cells and a murine melanoma model. Interestingly, we observe that, besides a high PTT efficacy, these copper sulfide NCs additionally possess intrinsic NIR induced photodynamic activity, whereupon they generate high levels of reactive oxygen species. Furthermore, in vitro and in vivo acute toxic responses of copper sulfide NCs were also elicited. This study highlights a mechanism of NIR light induced cancer therapy, which could pave the way toward more effective nanotherapeutics.

AB - Recently, plasmonic copper sulfide (Cu2-xS) nanocrystals (NCs) have attracted much attention as materials for photothermal therapy (PTT). Previous reports have correlated photoinduced cell death to the photothermal heat mechanism of these NCs, and no evidence of their photodynamic properties has been reported yet. Herein we have prepared physiologically stable near-infrared (NIR) plasmonic copper sulfide NCs and analyzed their photothermal and photodynamic properties, including therapeutic potential in cultured melanoma cells and a murine melanoma model. Interestingly, we observe that, besides a high PTT efficacy, these copper sulfide NCs additionally possess intrinsic NIR induced photodynamic activity, whereupon they generate high levels of reactive oxygen species. Furthermore, in vitro and in vivo acute toxic responses of copper sulfide NCs were also elicited. This study highlights a mechanism of NIR light induced cancer therapy, which could pave the way toward more effective nanotherapeutics.

KW - copper sulfide nanocrystals

KW - near-infrared light

KW - photodynamic therapy

KW - photothermal therapy

UR - http://www.scopus.com/inward/record.url?scp=84923392368&partnerID=8YFLogxK

U2 - 10.1021/nn506687t

DO - 10.1021/nn506687t

M3 - Article

C2 - 25603353

AN - SCOPUS:84923392368

SN - 1936-0851

VL - 9

SP - 1788

EP - 1800

JO - ACS Nano

JF - ACS Nano

IS - 2

ER -

Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this