TY - JOUR
T1 - Photocatalytic Decarboxylative Alkylation of the C2-Position of 3-Haloindoles with Aliphatic Carboxylic Acids
AU - Feng, Guanzheng
AU - Shen, Yisan
AU - Sun, Xiaojing
AU - Zhang, Wenjin
AU - Sun, Chenghui
AU - Ji, Weixiao
AU - Huang, He
AU - Pang, Siping
N1 - Publisher Copyright:
© 2025 American Chemical Society
PY - 2025/11/7
Y1 - 2025/11/7
N2 - Indole is one of the most prevalent structural frameworks. Notably, C2-substituted indoles bearing an unsubstituted C3-position are recognized as privileged structural motifs in pharmaceutical synthesis. Here, we report a transition-metal-free photocatalytic decarboxylative coupling strategy employing 4CzIPN as the photocatalyst, enabling efficient and dehalogenative C2 functionalization of 3-haloindoles under mild conditions. Moreover, the one-step direct functionalization protocol exhibits excellent scalability, highlighting the synthetic utility of this methodology.
AB - Indole is one of the most prevalent structural frameworks. Notably, C2-substituted indoles bearing an unsubstituted C3-position are recognized as privileged structural motifs in pharmaceutical synthesis. Here, we report a transition-metal-free photocatalytic decarboxylative coupling strategy employing 4CzIPN as the photocatalyst, enabling efficient and dehalogenative C2 functionalization of 3-haloindoles under mild conditions. Moreover, the one-step direct functionalization protocol exhibits excellent scalability, highlighting the synthetic utility of this methodology.
UR - https://www.scopus.com/pages/publications/105021022046
U2 - 10.1021/acs.joc.5c01872
DO - 10.1021/acs.joc.5c01872
M3 - Article
AN - SCOPUS:105021022046
SN - 0022-3263
VL - 90
SP - 15701
EP - 15706
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 44
ER -