Pharmacokinetic Study of Promethazine and Ephedrine Combination in Rats Under the Simulated Microgravity Condition

Lin Gan; Zhi Fen Zheng; Lu Jun Wang; Yu Lin Deng; Yu Juan Li

doi:10.15918/j.tbit1001-0645.2018.02.019

Pharmacokinetic Study of Promethazine and Ephedrine Combination in Rats Under the Simulated Microgravity Condition

Lin Gan, Zhi Fen Zheng, Lu Jun Wang, Yu Lin Deng, Yu Juan Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

To provide basic research data for astronauts to take medicine reasonably and safely, some pharmacokinetic studies on promethazine and ephedrine were carried out in rats' plasma to obtain the pharmacokinetic parameters in different simulated weightlessness periods. A rat tail-suspension model was used to simulate weightlessness, and an HPLC-MS/MS method was developed to determine the promethazine and ephedrine quantification in rat plasma. The pharmacokinetic parameters in simulated weightless group show the differences between control and model groups, such as the area under the concentration-time curve (A_UC0-t ), peak plasma concentration (C_max), elimination rate constant K_e and half-life (T_1/2). Different simulated weightlessness periods have a significant impact on the pharmacokinetic process of drugs in rats.

Original language	English
Pages (from-to)	216-220
Number of pages	5
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	38
Issue number	2
DOIs	https://doi.org/10.15918/j.tbit1001-0645.2018.02.019
Publication status	Published - 1 Feb 2018

Keywords

Ephedrine
Pharmacokinetics
Promethazine
Simulated microgravity

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10.15918/j.tbit1001-0645.2018.02.019

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title = "Pharmacokinetic Study of Promethazine and Ephedrine Combination in Rats Under the Simulated Microgravity Condition",

abstract = "To provide basic research data for astronauts to take medicine reasonably and safely, some pharmacokinetic studies on promethazine and ephedrine were carried out in rats' plasma to obtain the pharmacokinetic parameters in different simulated weightlessness periods. A rat tail-suspension model was used to simulate weightlessness, and an HPLC-MS/MS method was developed to determine the promethazine and ephedrine quantification in rat plasma. The pharmacokinetic parameters in simulated weightless group show the differences between control and model groups, such as the area under the concentration-time curve (AUC0-t ), peak plasma concentration (Cmax), elimination rate constant Ke and half-life (T1/2). Different simulated weightlessness periods have a significant impact on the pharmacokinetic process of drugs in rats.",

keywords = "Ephedrine, Pharmacokinetics, Promethazine, Simulated microgravity",

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AU - Gan, Lin

AU - Zheng, Zhi Fen

AU - Wang, Lu Jun

AU - Deng, Yu Lin

AU - Li, Yu Juan

PY - 2018/2/1

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N2 - To provide basic research data for astronauts to take medicine reasonably and safely, some pharmacokinetic studies on promethazine and ephedrine were carried out in rats' plasma to obtain the pharmacokinetic parameters in different simulated weightlessness periods. A rat tail-suspension model was used to simulate weightlessness, and an HPLC-MS/MS method was developed to determine the promethazine and ephedrine quantification in rat plasma. The pharmacokinetic parameters in simulated weightless group show the differences between control and model groups, such as the area under the concentration-time curve (AUC0-t ), peak plasma concentration (Cmax), elimination rate constant Ke and half-life (T1/2). Different simulated weightlessness periods have a significant impact on the pharmacokinetic process of drugs in rats.

AB - To provide basic research data for astronauts to take medicine reasonably and safely, some pharmacokinetic studies on promethazine and ephedrine were carried out in rats' plasma to obtain the pharmacokinetic parameters in different simulated weightlessness periods. A rat tail-suspension model was used to simulate weightlessness, and an HPLC-MS/MS method was developed to determine the promethazine and ephedrine quantification in rat plasma. The pharmacokinetic parameters in simulated weightless group show the differences between control and model groups, such as the area under the concentration-time curve (AUC0-t ), peak plasma concentration (Cmax), elimination rate constant Ke and half-life (T1/2). Different simulated weightlessness periods have a significant impact on the pharmacokinetic process of drugs in rats.

KW - Ephedrine

KW - Pharmacokinetics

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KW - Simulated microgravity

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Pharmacokinetic Study of Promethazine and Ephedrine Combination in Rats Under the Simulated Microgravity Condition

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