Persistent spiking activity underlies working memory

Christos Constantinidis; Shintaro Funahashi; Daeyeol Lee; John D. Murray; Xue Lian Qi; Min Wang; Amy F.T. Arnsten

doi:10.1523/JNEUROSCI.2486-17.2018

Persistent spiking activity underlies working memory

Christos Constantinidis^*, Shintaro Funahashi, Daeyeol Lee, John D. Murray, Xue Lian Qi, Min Wang, Amy F.T. Arnsten

^*Corresponding author for this work

Advanced Research Institute of Multidisciplinary Science

Research output: Contribution to journal › Article › peer-review

186 Citations (Scopus)

Abstract

Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.

Original language	English
Pages (from-to)	7020-7028
Number of pages	9
Journal	Journal of Neuroscience
Volume	38
Issue number	32
DOIs	https://doi.org/10.1523/JNEUROSCI.2486-17.2018
Publication status	Published - 8 Aug 2018

Keywords

Delay period
Monkey
Neurophysiology
Prefrontal cortex
Working memory

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10.1523/JNEUROSCI.2486-17.2018

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abstract = "Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.",

keywords = "Delay period, Monkey, Neurophysiology, Prefrontal cortex, Working memory",

author = "Christos Constantinidis and Shintaro Funahashi and Daeyeol Lee and Murray, {John D.} and Qi, {Xue Lian} and Min Wang and Arnsten, {Amy F.T.}",

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AU - Qi, Xue Lian

AU - Wang, Min

AU - Arnsten, Amy F.T.

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KW - Monkey

KW - Neurophysiology

KW - Prefrontal cortex

KW - Working memory

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Persistent spiking activity underlies working memory

Abstract

Keywords

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