Peptide functionalized targeting liposomes: For nanoscale drug delivery towards angiogenesis

Qiuju Han; Xiangqian Jia; Yixia Qian; Zihua Wang; Shu Yang; Yunhong Jia; Weizhi Wang; Zhiyuan Hu

doi:10.1039/c6tb01823h

Peptide functionalized targeting liposomes: For nanoscale drug delivery towards angiogenesis

Qiuju Han, Xiangqian Jia, Yixia Qian, Zihua Wang, Shu Yang, Yunhong Jia^*, Weizhi Wang, Zhiyuan Hu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a "one bead one compound" (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.

Original language	English
Pages (from-to)	7087-7091
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	44
DOIs	https://doi.org/10.1039/c6tb01823h
Publication status	Published - 2016
Externally published	Yes

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title = "Peptide functionalized targeting liposomes: For nanoscale drug delivery towards angiogenesis",

abstract = "A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a {"}one bead one compound{"} (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.",

author = "Qiuju Han and Xiangqian Jia and Yixia Qian and Zihua Wang and Shu Yang and Yunhong Jia and Weizhi Wang and Zhiyuan Hu",

note = "Publisher Copyright: {\textcopyright} 2016 Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6tb01823h",

language = "English",

volume = "4",

pages = "7087--7091",

journal = "Journal of Materials Chemistry B",

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publisher = "Royal Society of Chemistry",

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}

TY - JOUR

T1 - Peptide functionalized targeting liposomes

T2 - For nanoscale drug delivery towards angiogenesis

AU - Han, Qiuju

AU - Jia, Xiangqian

AU - Qian, Yixia

AU - Wang, Zihua

AU - Yang, Shu

AU - Jia, Yunhong

AU - Wang, Weizhi

AU - Hu, Zhiyuan

PY - 2016

Y1 - 2016

N2 - A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a "one bead one compound" (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.

AB - A novel affinity peptide S1 (LIDHEWKENYFPLSF) was screened out via a "one bead one compound" (OBOC) approach on a microarray device. It was identified that S1 could specifically recognize and bind to vascular endothelial growth factor receptor 2 (VEGFR2), which is an angiogenesis biomarker. Moreover, S1-functionalized liposomes (S1-LS) could achieve efficient nanoscale drug delivery under the conditions of VEGFR2-overexpression in vitro and in vivo. It was demonstrated that S1-LS would be a promising VEGFR2-targeting drug delivery system.

UR - https://www.scopus.com/pages/publications/84994516237

U2 - 10.1039/c6tb01823h

DO - 10.1039/c6tb01823h

M3 - Article

AN - SCOPUS:84994516237

SN - 2050-7518

VL - 4

SP - 7087

EP - 7091

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 44

ER -

Peptide functionalized targeting liposomes: For nanoscale drug delivery towards angiogenesis

Abstract

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