TY - JOUR
T1 - Pelvic Fracture Reduction Planning via Joint Shape-Intensity Reference
AU - Zhao, Xirui
AU - Xiao, Deqiang
AU - Zhang, Teng
AU - Shao, Long
AU - Ai, Danni
AU - Fan, Jingfan
AU - Fu, Tianyu
AU - Lin, Yucong
AU - Song, Hong
AU - Wang, Junqiang
AU - Yang, Jian
N1 - Publisher Copyright:
© 1982-2012 IEEE.
PY - 2025
Y1 - 2025
N2 - Pelvic fracture reduction planning is clinically critical yet technically demanding due to the complex anatomical structure of pelvis and the topological discontinuities introduced by fractures. Existing computer-assisted planning approaches dominantly rely on shape-based models, overlooking the rich CT intensity information that is essential for accurate and patient-specific planning. To address this limitation, we propose SIRDiff, a novel framework that incorporates anatomical shape and CT intensity information to generate biomechanically plausible reference models for pelvic fracture reduction planning. SIRDiff comprises three key components: 1) the structure-aware diffusion model to reconstruct the global anatomical structure, 2) the topology-adaptive structural conditioning strategy that maps fracture landmarks into a healthy anatomical graph domain for robust structure guidance, and 3) the detail-preserved autoencoder to ensure the fine-grained image reconstruction from latent representations. Additionally, SIRDiff adopts a multi-task learning approach to jointly predict the reference CT image and corresponding bone segmentation map, which enhances its potential for clinical application and ensures better anatomical consistency. Despite being trained exclusively on synthetic fracture data, SIRDiff shows the strong generalizability to real clinical cases and consistently outperforms existing methods across multiple clinically relevant evaluation metrics, demonstrating its potential as a robust and deployable solution for pelvic fracture reduction planning.
AB - Pelvic fracture reduction planning is clinically critical yet technically demanding due to the complex anatomical structure of pelvis and the topological discontinuities introduced by fractures. Existing computer-assisted planning approaches dominantly rely on shape-based models, overlooking the rich CT intensity information that is essential for accurate and patient-specific planning. To address this limitation, we propose SIRDiff, a novel framework that incorporates anatomical shape and CT intensity information to generate biomechanically plausible reference models for pelvic fracture reduction planning. SIRDiff comprises three key components: 1) the structure-aware diffusion model to reconstruct the global anatomical structure, 2) the topology-adaptive structural conditioning strategy that maps fracture landmarks into a healthy anatomical graph domain for robust structure guidance, and 3) the detail-preserved autoencoder to ensure the fine-grained image reconstruction from latent representations. Additionally, SIRDiff adopts a multi-task learning approach to jointly predict the reference CT image and corresponding bone segmentation map, which enhances its potential for clinical application and ensures better anatomical consistency. Despite being trained exclusively on synthetic fracture data, SIRDiff shows the strong generalizability to real clinical cases and consistently outperforms existing methods across multiple clinically relevant evaluation metrics, demonstrating its potential as a robust and deployable solution for pelvic fracture reduction planning.
KW - Surgical planning
KW - image generation
KW - landmark graph
KW - latent diffusion model
KW - pelvis fracture reduction
UR - https://www.scopus.com/pages/publications/105019589158
U2 - 10.1109/TMI.2025.3621670
DO - 10.1109/TMI.2025.3621670
M3 - Article
C2 - 41091615
AN - SCOPUS:105019589158
SN - 0278-0062
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
ER -