One-Pot Synthesis of Thiocyanato-Containing Polycyclic Indolones through Photo-Induced Cascade Radical Cyclization/Thiocyanation/Oxidation of N-Acylindoles

Chukai Shao; Longcan Chen; Ruirui Hua; Xinzhe Zhao; Xiaowei Liu; Rui Tian; Hongquan Yin; Kaixiang Liu; Fu Xue Chen

doi:10.1021/acs.joc.5c02353

One-Pot Synthesis of Thiocyanato-Containing Polycyclic Indolones through Photo-Induced Cascade Radical Cyclization/Thiocyanation/Oxidation of N-Acylindoles

Chukai Shao
, Longcan Chen
, Ruirui Hua
, Xinzhe Zhao
, Xiaowei Liu
, Rui Tian
, Hongquan Yin
, Kaixiang Liu
, Fu Xue Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A photoinduced radical cascade cyclization/thiocyanation of N-acylindoles has been developed to obtain a series of thiocyanato-containing [1,3]oxazino[3,4-a]indolones and indolo[2,1-b]quinazolin-12(5H)-ones. A wide scope of substrates has been tolerated in moderate to good yields under mild and metal-free conditions.

Original language	English
Pages (from-to)	2275-2283
Number of pages	9
Journal	Journal of Organic Chemistry
Volume	91
Issue number	5
DOIs	https://doi.org/10.1021/acs.joc.5c02353
Publication status	Published - 6 Feb 2026
Externally published	Yes

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10.1021/acs.joc.5c02353

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title = "One-Pot Synthesis of Thiocyanato-Containing Polycyclic Indolones through Photo-Induced Cascade Radical Cyclization/Thiocyanation/Oxidation of N-Acylindoles",

abstract = "A photoinduced radical cascade cyclization/thiocyanation of N-acylindoles has been developed to obtain a series of thiocyanato-containing [1,3]oxazino[3,4-a]indolones and indolo[2,1-b]quinazolin-12(5H)-ones. A wide scope of substrates has been tolerated in moderate to good yields under mild and metal-free conditions.",

author = "Chukai Shao and Longcan Chen and Ruirui Hua and Xinzhe Zhao and Xiaowei Liu and Rui Tian and Hongquan Yin and Kaixiang Liu and Chen, \{Fu Xue\}",

note = "Publisher Copyright: {\textcopyright} 2026 American Chemical Society",

year = "2026",

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day = "6",

doi = "10.1021/acs.joc.5c02353",

language = "English",

volume = "91",

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journal = "Journal of Organic Chemistry",

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TY - JOUR

T1 - One-Pot Synthesis of Thiocyanato-Containing Polycyclic Indolones through Photo-Induced Cascade Radical Cyclization/Thiocyanation/Oxidation of N-Acylindoles

AU - Shao, Chukai

AU - Chen, Longcan

AU - Hua, Ruirui

AU - Zhao, Xinzhe

AU - Liu, Xiaowei

AU - Tian, Rui

AU - Yin, Hongquan

AU - Liu, Kaixiang

AU - Chen, Fu Xue

PY - 2026/2/6

Y1 - 2026/2/6

N2 - A photoinduced radical cascade cyclization/thiocyanation of N-acylindoles has been developed to obtain a series of thiocyanato-containing [1,3]oxazino[3,4-a]indolones and indolo[2,1-b]quinazolin-12(5H)-ones. A wide scope of substrates has been tolerated in moderate to good yields under mild and metal-free conditions.

AB - A photoinduced radical cascade cyclization/thiocyanation of N-acylindoles has been developed to obtain a series of thiocyanato-containing [1,3]oxazino[3,4-a]indolones and indolo[2,1-b]quinazolin-12(5H)-ones. A wide scope of substrates has been tolerated in moderate to good yields under mild and metal-free conditions.

UR - https://www.scopus.com/pages/publications/105029466742

U2 - 10.1021/acs.joc.5c02353

DO - 10.1021/acs.joc.5c02353

M3 - Article

AN - SCOPUS:105029466742

SN - 0022-3263

VL - 91

SP - 2275

EP - 2283

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 5

ER -

One-Pot Synthesis of Thiocyanato-Containing Polycyclic Indolones through Photo-Induced Cascade Radical Cyclization/Thiocyanation/Oxidation of N-Acylindoles

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