OBOC screening of high activity and low-toxic polymyxin analogs against MCR-1 resistant strains

Wenhong Zheng; Xin Wang; Hao Lian; Pengfei Zou; Tongyi Sun; Hao Wang; Li Li Li

doi:10.1039/d5bm00362h

OBOC screening of high activity and low-toxic polymyxin analogs against MCR-1 resistant strains

Wenhong Zheng
, Xin Wang
, Hao Lian
, Pengfei Zou
, Tongyi Sun^*
, Hao Wang^*
, Li Li Li^*

^*Corresponding author for this work

University Weifang
National Center for Nanoscience and Technology
Beijing University of Chemical Technology
Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We performed inverse synthesis to create 1152 structural analogs of polymyxin B with modified hydrophilicity and charge properties using OBOC technology. This led to the identification of two promising candidates that provided insights into structure-activity relationships. These compounds maintained high antibacterial activity while expanding the safety window 4-16 times.

Original language	English
Pages (from-to)	2651-2655
Number of pages	5
Journal	Biomaterials Science
Volume	13
Issue number	10
DOIs	https://doi.org/10.1039/d5bm00362h
Publication status	Published - 27 Mar 2025
Externally published	Yes

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title = "OBOC screening of high activity and low-toxic polymyxin analogs against MCR-1 resistant strains",

abstract = "We performed inverse synthesis to create 1152 structural analogs of polymyxin B with modified hydrophilicity and charge properties using OBOC technology. This led to the identification of two promising candidates that provided insights into structure-activity relationships. These compounds maintained high antibacterial activity while expanding the safety window 4-16 times.",

author = "Wenhong Zheng and Xin Wang and Hao Lian and Pengfei Zou and Tongyi Sun and Hao Wang and Li, \{Li Li\}",

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T1 - OBOC screening of high activity and low-toxic polymyxin analogs against MCR-1 resistant strains

AU - Zheng, Wenhong

AU - Wang, Xin

AU - Lian, Hao

AU - Zou, Pengfei

AU - Sun, Tongyi

AU - Wang, Hao

AU - Li, Li Li

PY - 2025/3/27

Y1 - 2025/3/27

N2 - We performed inverse synthesis to create 1152 structural analogs of polymyxin B with modified hydrophilicity and charge properties using OBOC technology. This led to the identification of two promising candidates that provided insights into structure-activity relationships. These compounds maintained high antibacterial activity while expanding the safety window 4-16 times.

AB - We performed inverse synthesis to create 1152 structural analogs of polymyxin B with modified hydrophilicity and charge properties using OBOC technology. This led to the identification of two promising candidates that provided insights into structure-activity relationships. These compounds maintained high antibacterial activity while expanding the safety window 4-16 times.

UR - https://www.scopus.com/pages/publications/105001945129

U2 - 10.1039/d5bm00362h

DO - 10.1039/d5bm00362h

M3 - Article

C2 - 40178230

AN - SCOPUS:105001945129

SN - 2047-4830

VL - 13

SP - 2651

EP - 2655

JO - Biomaterials Science

JF - Biomaterials Science

IS - 10

ER -

OBOC screening of high activity and low-toxic polymyxin analogs against MCR-1 resistant strains

Abstract

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