Novel supramolecular hydrogels made via michael-type addition reaction of dithiothreitol with self-assembly of α-cyclodextrins and acryloyl-terminated 3-arm PEG

Dan Dan Hou; Xue Geng; Lin Ye; Ai Ying Zhang; Zeng Guo Feng

doi:10.1007/s11706-010-0010-7

Novel supramolecular hydrogels made via michael-type addition reaction of dithiothreitol with self-assembly of α-cyclodextrins and acryloyl-terminated 3-arm PEG

Dan Dan Hou, Xue Geng, Lin Ye, Ai Ying Zhang, Zeng Guo Feng^*

^*Corresponding author for this work

School of Material Science and Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A kind of novel three-dimensional crosslinked hydrogel was synthesized via Michael-type addition reaction of dithiothreitol (DTT) as a crosslinker/extender towards the self-assembly of α-cyclodextrins (α-CDs) with acryloyl end capped 3-arm PEG. The supramolecular structure of the resulting hydrogels was characterized by using FT-IR, TGA, XRD and DSC measurements. The effect of varying the amount of α-CDs was studied on the crosslinking process. Interestingly, this conjugation reaction is smoothly carried out at physiological temperature and pH in the absence of any sensitizer or catalyst. It appears that these chemically crosslinked hydrogels have the potential to be used as carriers for drug controlled release and scaffolds for injectable tissue engineering.

Original language	English
Pages (from-to)	70-77
Number of pages	8
Journal	Frontiers of Materials Science in China
Volume	4
Issue number	1
DOIs	https://doi.org/10.1007/s11706-010-0010-7
Publication status	Published - Feb 2010

Keywords

Dithiothreitol (DTT)
Michael-type addition reaction
Self-assembly
Supramolecular structured hydrogel
α-cyclodextrin (α-CD)

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10.1007/s11706-010-0010-7

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title = "Novel supramolecular hydrogels made via michael-type addition reaction of dithiothreitol with self-assembly of α-cyclodextrins and acryloyl-terminated 3-arm PEG",

abstract = "A kind of novel three-dimensional crosslinked hydrogel was synthesized via Michael-type addition reaction of dithiothreitol (DTT) as a crosslinker/extender towards the self-assembly of α-cyclodextrins (α-CDs) with acryloyl end capped 3-arm PEG. The supramolecular structure of the resulting hydrogels was characterized by using FT-IR, TGA, XRD and DSC measurements. The effect of varying the amount of α-CDs was studied on the crosslinking process. Interestingly, this conjugation reaction is smoothly carried out at physiological temperature and pH in the absence of any sensitizer or catalyst. It appears that these chemically crosslinked hydrogels have the potential to be used as carriers for drug controlled release and scaffolds for injectable tissue engineering.",

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author = "Hou, {Dan Dan} and Xue Geng and Lin Ye and Zhang, {Ai Ying} and Feng, {Zeng Guo}",

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AU - Geng, Xue

AU - Ye, Lin

AU - Zhang, Ai Ying

AU - Feng, Zeng Guo

PY - 2010/2

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AB - A kind of novel three-dimensional crosslinked hydrogel was synthesized via Michael-type addition reaction of dithiothreitol (DTT) as a crosslinker/extender towards the self-assembly of α-cyclodextrins (α-CDs) with acryloyl end capped 3-arm PEG. The supramolecular structure of the resulting hydrogels was characterized by using FT-IR, TGA, XRD and DSC measurements. The effect of varying the amount of α-CDs was studied on the crosslinking process. Interestingly, this conjugation reaction is smoothly carried out at physiological temperature and pH in the absence of any sensitizer or catalyst. It appears that these chemically crosslinked hydrogels have the potential to be used as carriers for drug controlled release and scaffolds for injectable tissue engineering.

KW - Dithiothreitol (DTT)

KW - Michael-type addition reaction

KW - Self-assembly

KW - Supramolecular structured hydrogel

KW - α-cyclodextrin (α-CD)

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Novel supramolecular hydrogels made via michael-type addition reaction of dithiothreitol with self-assembly of α-cyclodextrins and acryloyl-terminated 3-arm PEG

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Keywords

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