Neuroscience research based on microelectrode arrays and microfluidic technology

Wentao Zhang; Kai Han; Xiaolu Miao; Xiaowei Zhang; Qinsong Wei; Jiaqing Li; Bo Wang; Ying Qi; Beilei Sun; Yongming Li; Weizhi Wang

doi:10.1016/j.jpba.2025.117245

Neuroscience research based on microelectrode arrays and microfluidic technology

Wentao Zhang
, Kai Han
, Xiaolu Miao
, Xiaowei Zhang
, Qinsong Wei
, Jiaqing Li
, Bo Wang
, Ying Qi
, Beilei Sun
, Yongming Li^*
, Weizhi Wang

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Review article › peer-review

Abstract

The combination of microfluidic technology and Microelectrode Arrays (MEAs) provides a powerful tool for neuroscience research. It enables the construction, manipulation, and study of neuronal networks in a controllable in vitro environment, revealing the relationship between their structure and function, and bringing new breakthroughs to fields such as disease modeling, drug screening, and neural interface development. This article will review the relevant research on microfluidic technology and MEA in the field of neuroscience from aspects such as the design principles, preparation, and application research of microfluidic chips and MEA in the neural field.

Original language	English
Article number	117245
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	269
DOIs	https://doi.org/10.1016/j.jpba.2025.117245
Publication status	Published - 15 Feb 2026
Externally published	Yes

Keywords

Microelectrode Array (MEA)
Microfluidic technology
Neuroscience

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10.1016/j.jpba.2025.117245

Cite this

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title = "Neuroscience research based on microelectrode arrays and microfluidic technology",

abstract = "The combination of microfluidic technology and Microelectrode Arrays (MEAs) provides a powerful tool for neuroscience research. It enables the construction, manipulation, and study of neuronal networks in a controllable in vitro environment, revealing the relationship between their structure and function, and bringing new breakthroughs to fields such as disease modeling, drug screening, and neural interface development. This article will review the relevant research on microfluidic technology and MEA in the field of neuroscience from aspects such as the design principles, preparation, and application research of microfluidic chips and MEA in the neural field.",

keywords = "Microelectrode Array (MEA), Microfluidic technology, Neuroscience",

author = "Wentao Zhang and Kai Han and Xiaolu Miao and Xiaowei Zhang and Qinsong Wei and Jiaqing Li and Bo Wang and Ying Qi and Beilei Sun and Yongming Li and Weizhi Wang",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier B.V.",

year = "2026",

month = feb,

day = "15",

doi = "10.1016/j.jpba.2025.117245",

language = "English",

volume = "269",

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TY - JOUR

T1 - Neuroscience research based on microelectrode arrays and microfluidic technology

AU - Zhang, Wentao

AU - Han, Kai

AU - Miao, Xiaolu

AU - Zhang, Xiaowei

AU - Wei, Qinsong

AU - Li, Jiaqing

AU - Wang, Bo

AU - Qi, Ying

AU - Sun, Beilei

AU - Li, Yongming

AU - Wang, Weizhi

PY - 2026/2/15

Y1 - 2026/2/15

N2 - The combination of microfluidic technology and Microelectrode Arrays (MEAs) provides a powerful tool for neuroscience research. It enables the construction, manipulation, and study of neuronal networks in a controllable in vitro environment, revealing the relationship between their structure and function, and bringing new breakthroughs to fields such as disease modeling, drug screening, and neural interface development. This article will review the relevant research on microfluidic technology and MEA in the field of neuroscience from aspects such as the design principles, preparation, and application research of microfluidic chips and MEA in the neural field.

AB - The combination of microfluidic technology and Microelectrode Arrays (MEAs) provides a powerful tool for neuroscience research. It enables the construction, manipulation, and study of neuronal networks in a controllable in vitro environment, revealing the relationship between their structure and function, and bringing new breakthroughs to fields such as disease modeling, drug screening, and neural interface development. This article will review the relevant research on microfluidic technology and MEA in the field of neuroscience from aspects such as the design principles, preparation, and application research of microfluidic chips and MEA in the neural field.

KW - Microelectrode Array (MEA)

KW - Microfluidic technology

KW - Neuroscience

UR - https://www.scopus.com/pages/publications/105022478878

U2 - 10.1016/j.jpba.2025.117245

DO - 10.1016/j.jpba.2025.117245

M3 - Review article

C2 - 41259992

AN - SCOPUS:105022478878

SN - 0731-7085

VL - 269

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

M1 - 117245

ER -

Neuroscience research based on microelectrode arrays and microfluidic technology

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Keywords

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