Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

Wei Wang; Mengjun Li; Zining Liu; Jiayin Chen; Ke Liu; Fengfang Wei; Junrui Li; Yixuan Xie; Yushan Jiang; Tyuji Hoshino; Vladislav Victorovich Khrustalev; Minghui Yang; Hua Ma; Ruilin Zhang; Chenguang Shen; Yuhui Liao

doi:10.1002/EXP.20240253

Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

Wei Wang
, Mengjun Li
, Zining Liu
, Jiayin Chen
, Ke Liu
, Fengfang Wei
, Junrui Li
, Yixuan Xie
, Yushan Jiang
, Tyuji Hoshino
, Vladislav Victorovich Khrustalev
, Minghui Yang^*
, Hua Ma^*
, Ruilin Zhang^*
, Chenguang Shen^*
, Yuhui Liao^*

^*Corresponding author for this work

Kunming Medical College
Southern Medical University
Putian University
Hainan Medical College Affiliated Danzhou People's Hospital
Chiba University
Belarusian State Medical University
Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The recent monkeypox (MPOX) outbreak has drawn heightened international concern; however, no effective therapeutic interventions or reliable strategies to prevent its spread are currently available. Here, we developed a nano-silver (Ag)-selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti-inflammatory activity and accelerated the healing process of virus-infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.

Original language	English
Article number	20240253
Journal	Exploration
Volume	6
Issue number	3
DOIs	https://doi.org/10.1002/EXP.20240253
Publication status	Published - Jun 2026
Externally published	Yes

Keywords

antiviral therapy
liquid dressing
monkeypox
nano-silver-selenium
transmission blockage

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10.1002/EXP.20240253

Cite this

Wang, W., Li, M., Liu, Z., Chen, J., Liu, K., Wei, F., Li, J., Xie, Y., Jiang, Y., Hoshino, T., Khrustalev, V. V., Yang, M., Ma, H., Zhang, R., Shen, C., & Liao, Y. (2026). Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model. Exploration, 6(3), Article 20240253. https://doi.org/10.1002/EXP.20240253

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title = "Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model",

abstract = "The recent monkeypox (MPOX) outbreak has drawn heightened international concern; however, no effective therapeutic interventions or reliable strategies to prevent its spread are currently available. Here, we developed a nano-silver (Ag)-selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti-inflammatory activity and accelerated the healing process of virus-infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.",

keywords = "antiviral therapy, liquid dressing, monkeypox, nano-silver-selenium, transmission blockage",

author = "Wei Wang and Mengjun Li and Zining Liu and Jiayin Chen and Ke Liu and Fengfang Wei and Junrui Li and Yixuan Xie and Yushan Jiang and Tyuji Hoshino and Khrustalev, \{Vladislav Victorovich\} and Minghui Yang and Hua Ma and Ruilin Zhang and Chenguang Shen and Yuhui Liao",

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year = "2026",

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doi = "10.1002/EXP.20240253",

language = "English",

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journal = "Exploration",

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T1 - Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

AU - Wang, Wei

AU - Li, Mengjun

AU - Liu, Zining

AU - Chen, Jiayin

AU - Liu, Ke

AU - Wei, Fengfang

AU - Li, Junrui

AU - Xie, Yixuan

AU - Jiang, Yushan

AU - Hoshino, Tyuji

AU - Khrustalev, Vladislav Victorovich

AU - Yang, Minghui

AU - Ma, Hua

AU - Zhang, Ruilin

AU - Shen, Chenguang

AU - Liao, Yuhui

PY - 2026/6

Y1 - 2026/6

N2 - The recent monkeypox (MPOX) outbreak has drawn heightened international concern; however, no effective therapeutic interventions or reliable strategies to prevent its spread are currently available. Here, we developed a nano-silver (Ag)-selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti-inflammatory activity and accelerated the healing process of virus-infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.

AB - The recent monkeypox (MPOX) outbreak has drawn heightened international concern; however, no effective therapeutic interventions or reliable strategies to prevent its spread are currently available. Here, we developed a nano-silver (Ag)-selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti-inflammatory activity and accelerated the healing process of virus-infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.

KW - antiviral therapy

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KW - transmission blockage

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ER -

Nano-Silver-Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

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