Nano Pt@ZIF8 modified electrode and its application to detect sarcosine

Haipeng Yang; Junjun Wang; Chun Yang; Xiaolin Zhao; Shenghui Xie; Zaochuan Ge

doi:10.1149/2.1231805jes

Nano Pt@ZIF8 modified electrode and its application to detect sarcosine

Haipeng Yang, Junjun Wang, Chun Yang, Xiaolin Zhao, Shenghui Xie, Zaochuan Ge^*

^*Corresponding author for this work

Shenzhen University

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Sarcosine is a newly discovered effective biomarker for prostate cancer. However, the low concentration of sarcosine in tissue cells, plasma or urine blocks the development of sarcosine biosensors. In this manuscript, porous zeolitic imidazolate framework-8 (ZIF8) was synthesized and was used as carriers to load nano platinum (Pt@ZIF8). The porous structure of ZIF8 helped to stabilize the nano platinum and keep its high catalytic activity. The Pt@ZIF8 modified sarcosine biosensor had good response toward sarcosine due to its unique structure and morphology. The linear range of the as prepared biosensor is from 5 to 30 μM, which is consistent with the detection demand. The prepared sarcosine biosensor is suitable to be developed as a kind of portable diagnostic facilities for prostate cancer.

Original language	English
Pages (from-to)	H247-H250
Journal	Journal of the Electrochemical Society
Volume	165
Issue number	5
DOIs	https://doi.org/10.1149/2.1231805jes
Publication status	Published - 2018
Externally published	Yes

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title = "Nano Pt@ZIF8 modified electrode and its application to detect sarcosine",

abstract = "Sarcosine is a newly discovered effective biomarker for prostate cancer. However, the low concentration of sarcosine in tissue cells, plasma or urine blocks the development of sarcosine biosensors. In this manuscript, porous zeolitic imidazolate framework-8 (ZIF8) was synthesized and was used as carriers to load nano platinum (Pt@ZIF8). The porous structure of ZIF8 helped to stabilize the nano platinum and keep its high catalytic activity. The Pt@ZIF8 modified sarcosine biosensor had good response toward sarcosine due to its unique structure and morphology. The linear range of the as prepared biosensor is from 5 to 30 μM, which is consistent with the detection demand. The prepared sarcosine biosensor is suitable to be developed as a kind of portable diagnostic facilities for prostate cancer.",

author = "Haipeng Yang and Junjun Wang and Chun Yang and Xiaolin Zhao and Shenghui Xie and Zaochuan Ge",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018.",

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language = "English",

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pages = "H247--H250",

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TY - JOUR

T1 - Nano Pt@ZIF8 modified electrode and its application to detect sarcosine

AU - Yang, Haipeng

AU - Wang, Junjun

AU - Yang, Chun

AU - Zhao, Xiaolin

AU - Xie, Shenghui

AU - Ge, Zaochuan

PY - 2018

Y1 - 2018

N2 - Sarcosine is a newly discovered effective biomarker for prostate cancer. However, the low concentration of sarcosine in tissue cells, plasma or urine blocks the development of sarcosine biosensors. In this manuscript, porous zeolitic imidazolate framework-8 (ZIF8) was synthesized and was used as carriers to load nano platinum (Pt@ZIF8). The porous structure of ZIF8 helped to stabilize the nano platinum and keep its high catalytic activity. The Pt@ZIF8 modified sarcosine biosensor had good response toward sarcosine due to its unique structure and morphology. The linear range of the as prepared biosensor is from 5 to 30 μM, which is consistent with the detection demand. The prepared sarcosine biosensor is suitable to be developed as a kind of portable diagnostic facilities for prostate cancer.

AB - Sarcosine is a newly discovered effective biomarker for prostate cancer. However, the low concentration of sarcosine in tissue cells, plasma or urine blocks the development of sarcosine biosensors. In this manuscript, porous zeolitic imidazolate framework-8 (ZIF8) was synthesized and was used as carriers to load nano platinum (Pt@ZIF8). The porous structure of ZIF8 helped to stabilize the nano platinum and keep its high catalytic activity. The Pt@ZIF8 modified sarcosine biosensor had good response toward sarcosine due to its unique structure and morphology. The linear range of the as prepared biosensor is from 5 to 30 μM, which is consistent with the detection demand. The prepared sarcosine biosensor is suitable to be developed as a kind of portable diagnostic facilities for prostate cancer.

UR - https://www.scopus.com/pages/publications/85046693110

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DO - 10.1149/2.1231805jes

M3 - Article

AN - SCOPUS:85046693110

SN - 0013-4651

VL - 165

SP - H247-H250

JO - Journal of the Electrochemical Society

JF - Journal of the Electrochemical Society

IS - 5

ER -

Nano Pt@ZIF8 modified electrode and its application to detect sarcosine

Abstract

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