Multifunctional Photothermal Hydrogel in the Second Near-Infrared Window for Localized Tumor Therapy

Sha Lu; Yingjiao Wu; Yandi Liu; Xiaoyi Sun; Jianghua Li; Juan Li

doi:10.1021/acsabm.3c00492

Multifunctional Photothermal Hydrogel in the Second Near-Infrared Window for Localized Tumor Therapy

Sha Lu, Yingjiao Wu, Yandi Liu, Xiaoyi Sun, Jianghua Li^*, Juan Li^*

^*Corresponding author for this work

Central South University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A copper selenide-embedded gellan gum hydrogel (Cu_2-xSe@GG) is designed as an “all-in-one” antitumor agent. The obtained nanocomposite hydrogel exhibits strong near-infrared light absorption and high photothermal conversion efficiency in both the NIR-I and NIR-II biowindows. The photothermal conversion efficiency achieves 58.8% under the irradiation of 0.75 W/cm² with a 1064 nm laser. Furthermore, the nanocomposite hydrogel has catalase- and peroxidase-mimicking activities, which could alter the tumor microenvironment by reducing hypoxia and/or increasing the production of reactive oxygen species. Moreover, the multifunctional Cu_2-xSe@GG nanocomposite hydrogel can also be used as an immune agonist resiquimod (R848) carrier to promote immune regulation and enhance the therapeutic effect. The single-syringe R848/Cu_2-xSe@GG treatment achieves synergetic photothermal immunotherapy, showing 97.4%

Original language	English
Pages (from-to)	4694-4702
Number of pages	9
Journal	ACS Applied Bio Materials
Volume	6
Issue number	11
DOIs	https://doi.org/10.1021/acsabm.3c00492
Publication status	Published - 20 Nov 2023
Externally published	Yes

Keywords

copper selenide
hydrogel
immune agonist
nanozyme
photothermal therapy

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10.1021/acsabm.3c00492

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@article{cc0271bfa60d4742a767c44b9eeaac45,

title = "Multifunctional Photothermal Hydrogel in the Second Near-Infrared Window for Localized Tumor Therapy",

abstract = "A copper selenide-embedded gellan gum hydrogel (Cu2-xSe@GG) is designed as an “all-in-one” antitumor agent. The obtained nanocomposite hydrogel exhibits strong near-infrared light absorption and high photothermal conversion efficiency in both the NIR-I and NIR-II biowindows. The photothermal conversion efficiency achieves 58.8% under the irradiation of 0.75 W/cm2 with a 1064 nm laser. Furthermore, the nanocomposite hydrogel has catalase- and peroxidase-mimicking activities, which could alter the tumor microenvironment by reducing hypoxia and/or increasing the production of reactive oxygen species. Moreover, the multifunctional Cu2-xSe@GG nanocomposite hydrogel can also be used as an immune agonist resiquimod (R848) carrier to promote immune regulation and enhance the therapeutic effect. The single-syringe R848/Cu2-xSe@GG treatment achieves synergetic photothermal immunotherapy, showing 97.4%",

keywords = "copper selenide, hydrogel, immune agonist, nanozyme, photothermal therapy",

author = "Sha Lu and Yingjiao Wu and Yandi Liu and Xiaoyi Sun and Jianghua Li and Juan Li",

note = "Publisher Copyright: {\textcopyright} 2023 American Chemical Society.",

year = "2023",

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doi = "10.1021/acsabm.3c00492",

language = "English",

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journal = "ACS Applied Bio Materials",

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TY - JOUR

T1 - Multifunctional Photothermal Hydrogel in the Second Near-Infrared Window for Localized Tumor Therapy

AU - Lu, Sha

AU - Wu, Yingjiao

AU - Liu, Yandi

AU - Sun, Xiaoyi

AU - Li, Jianghua

AU - Li, Juan

PY - 2023/11/20

Y1 - 2023/11/20

N2 - A copper selenide-embedded gellan gum hydrogel (Cu2-xSe@GG) is designed as an “all-in-one” antitumor agent. The obtained nanocomposite hydrogel exhibits strong near-infrared light absorption and high photothermal conversion efficiency in both the NIR-I and NIR-II biowindows. The photothermal conversion efficiency achieves 58.8% under the irradiation of 0.75 W/cm2 with a 1064 nm laser. Furthermore, the nanocomposite hydrogel has catalase- and peroxidase-mimicking activities, which could alter the tumor microenvironment by reducing hypoxia and/or increasing the production of reactive oxygen species. Moreover, the multifunctional Cu2-xSe@GG nanocomposite hydrogel can also be used as an immune agonist resiquimod (R848) carrier to promote immune regulation and enhance the therapeutic effect. The single-syringe R848/Cu2-xSe@GG treatment achieves synergetic photothermal immunotherapy, showing 97.4%

AB - A copper selenide-embedded gellan gum hydrogel (Cu2-xSe@GG) is designed as an “all-in-one” antitumor agent. The obtained nanocomposite hydrogel exhibits strong near-infrared light absorption and high photothermal conversion efficiency in both the NIR-I and NIR-II biowindows. The photothermal conversion efficiency achieves 58.8% under the irradiation of 0.75 W/cm2 with a 1064 nm laser. Furthermore, the nanocomposite hydrogel has catalase- and peroxidase-mimicking activities, which could alter the tumor microenvironment by reducing hypoxia and/or increasing the production of reactive oxygen species. Moreover, the multifunctional Cu2-xSe@GG nanocomposite hydrogel can also be used as an immune agonist resiquimod (R848) carrier to promote immune regulation and enhance the therapeutic effect. The single-syringe R848/Cu2-xSe@GG treatment achieves synergetic photothermal immunotherapy, showing 97.4%

KW - copper selenide

KW - hydrogel

KW - immune agonist

KW - nanozyme

KW - photothermal therapy

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U2 - 10.1021/acsabm.3c00492

DO - 10.1021/acsabm.3c00492

M3 - Article

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AN - SCOPUS:85176790957

SN - 2576-6422

VL - 6

SP - 4694

EP - 4702

JO - ACS Applied Bio Materials

JF - ACS Applied Bio Materials

IS - 11

ER -

Multifunctional Photothermal Hydrogel in the Second Near-Infrared Window for Localized Tumor Therapy

Abstract

Keywords

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