Multifunctional Biopolymer Nanoparticles for Drug Delivery and Protein Immobilization

Jia Li, Feijun Wang*, Dandan Shi, Yunhua Zhang, Ziqiang Shao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Nanoparticles have attracted a great deal of attention because of their broad range of application in biotechnology and nanomedicine. In this paper, magnetic-fluorescent nanoparticles based on iron oxide and biopolymer (chitosan and carboxymethyl cellulose) were fabricated. Using a layer-by-layer approach, two core-shell type architectures could be formed in the nanoparticles: (1) fluorescent groups placed in the outer layer or (2) with-in the layers consisting of cationic poly-electrolyte. Both of these particles showed superparamagnetic and strong fluorescent properties. The nanoparticles had higher encapsulation efficiency and pH-sensitive drug release over a long time.

Original languageEnglish
Pages (from-to)156-167
Number of pages12
JournalFerroelectrics
Volume486
Issue number1
DOIs
Publication statusPublished - 17 Sept 2015

Keywords

  • Magnetic
  • biopolymer
  • drug delivery
  • fluorescent
  • nanoparticle

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