Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation

Lei Ren; Yangnan Hu; Xiaoqiong Ding; Menghui Liao; Tian Shen; Sixing Cao; Hui Zhang; Hong Cheng; Yanru Qi; Pan Feng; Xinyi Pang; Ling Lu; Huan Wang; Wenwen Liu; Renjie Chai; Lin Cheng

doi:10.1002/advs.202412158

Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation

Lei Ren, Yangnan Hu^*, Xiaoqiong Ding, Menghui Liao, Tian Shen, Sixing Cao, Hui Zhang, Hong Cheng, Yanru Qi, Pan Feng, Xinyi Pang, Ling Lu^*, Huan Wang^*, Wenwen Liu^*, Renjie Chai^*, Lin Cheng^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA-PDMS)-coated cochlear electrode is presented for CI and hearing protection. The porous MA-PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti₃C₂T_x MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug-loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system.

Original language	English
Article number	2412158
Journal	Advanced Science
Volume	12
Issue number	21
DOIs	https://doi.org/10.1002/advs.202412158
Publication status	Published - 5 Jun 2025
Externally published	Yes

Keywords

antifibrosis
cochlear electrode
hydrogel
porous PDMS
tissue engineering

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10.1002/advs.202412158

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title = "Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation",

abstract = "Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA-PDMS)-coated cochlear electrode is presented for CI and hearing protection. The porous MA-PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti3C2Tx MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug-loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system.",

keywords = "antifibrosis, cochlear electrode, hydrogel, porous PDMS, tissue engineering",

author = "Lei Ren and Yangnan Hu and Xiaoqiong Ding and Menghui Liao and Tian Shen and Sixing Cao and Hui Zhang and Hong Cheng and Yanru Qi and Pan Feng and Xinyi Pang and Ling Lu and Huan Wang and Wenwen Liu and Renjie Chai and Lin Cheng",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH.",

year = "2025",

month = jun,

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doi = "10.1002/advs.202412158",

language = "English",

volume = "12",

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TY - JOUR

T1 - Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation

AU - Ren, Lei

AU - Hu, Yangnan

AU - Ding, Xiaoqiong

AU - Liao, Menghui

AU - Shen, Tian

AU - Cao, Sixing

AU - Zhang, Hui

AU - Cheng, Hong

AU - Qi, Yanru

AU - Feng, Pan

AU - Pang, Xinyi

AU - Lu, Ling

AU - Wang, Huan

AU - Liu, Wenwen

AU - Chai, Renjie

AU - Cheng, Lin

PY - 2025/6/5

Y1 - 2025/6/5

N2 - Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA-PDMS)-coated cochlear electrode is presented for CI and hearing protection. The porous MA-PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti3C2Tx MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug-loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system.

AB - Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA-PDMS)-coated cochlear electrode is presented for CI and hearing protection. The porous MA-PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti3C2Tx MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug-loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system.

KW - antifibrosis

KW - cochlear electrode

KW - hydrogel

KW - porous PDMS

KW - tissue engineering

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U2 - 10.1002/advs.202412158

DO - 10.1002/advs.202412158

M3 - Article

AN - SCOPUS:105004841746

SN - 2198-3844

VL - 12

JO - Advanced Science

JF - Advanced Science

IS - 21

M1 - 2412158

ER -

Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation

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