Miniaturized optical resolution photoacoustic microscope based on a microelectromechanical systems scanning mirror

In this paper, we report a miniaturized optical resolution photoacoustic microscopy system based on amicroelectromechanical system(MEMS) scanningmirror. Atwo-dimensionalMEMS scanning mirror was used to achieve raster scanning of the excitation optical focus. The wideband photoacoustic signals were detected by a flat ultrasound transducer with a center frequency of 10MHz and an active area of 2 mm in diameter. The size and weight of this device were 60 mm × 30 mm × 20 mm and 40 g, respectively. We evaluated this system using sharp blades, carbon fibers, and a silver strip target. In vivo experiments of imaging vasculatures in the mouse ear, brain, and human lip were completed to demonstrate its potential for biological and clinical applications.