Miniature fluorescence molecular tomography (FMT) endoscope based on a MEMS scanning mirror and an optical fiberscope

Hao Yang; Dingkang Wang; Tianqi Shan; Xianjin Dai; Huikai Xie; Lily Yang; Huabei Jiang

doi:10.1088/1361-6560/ab23b3

Miniature fluorescence molecular tomography (FMT) endoscope based on a MEMS scanning mirror and an optical fiberscope

Hao Yang^*, Dingkang Wang, Tianqi Shan, Xianjin Dai, Huikai Xie, Lily Yang, Huabei Jiang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We present a novel FMT endoscope by using a MEMS scanning mirror and an optical fiberscope. The diameter of this highly miniaturized FMT device is only 5 mm. To our knowledge, this is the smallest FMT device we found so far. Several phantom experiments based on indocyanine green (ICG) were conducted to demonstrate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (ATF-PEG-IO-830) and were then imaged to further demonstrate the ability of this FMT endoscope for imaging small animals.

Original language	English
Article number	125015
Journal	Physics in Medicine and Biology
Volume	64
Issue number	12
DOIs	https://doi.org/10.1088/1361-6560/ab23b3
Publication status	Published - 20 Jun 2019
Externally published	Yes

Keywords

MEMS mirror
endoscope
fluorescence molecular tomography
optical fiberscope

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10.1088/1361-6560/ab23b3

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title = "Miniature fluorescence molecular tomography (FMT) endoscope based on a MEMS scanning mirror and an optical fiberscope",

abstract = "We present a novel FMT endoscope by using a MEMS scanning mirror and an optical fiberscope. The diameter of this highly miniaturized FMT device is only 5 mm. To our knowledge, this is the smallest FMT device we found so far. Several phantom experiments based on indocyanine green (ICG) were conducted to demonstrate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (ATF-PEG-IO-830) and were then imaged to further demonstrate the ability of this FMT endoscope for imaging small animals.",

keywords = "MEMS mirror, endoscope, fluorescence molecular tomography, optical fiberscope",

author = "Hao Yang and Dingkang Wang and Tianqi Shan and Xianjin Dai and Huikai Xie and Lily Yang and Huabei Jiang",

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AU - Yang, Hao

AU - Wang, Dingkang

AU - Shan, Tianqi

AU - Dai, Xianjin

AU - Xie, Huikai

AU - Yang, Lily

AU - Jiang, Huabei

PY - 2019/6/20

Y1 - 2019/6/20

N2 - We present a novel FMT endoscope by using a MEMS scanning mirror and an optical fiberscope. The diameter of this highly miniaturized FMT device is only 5 mm. To our knowledge, this is the smallest FMT device we found so far. Several phantom experiments based on indocyanine green (ICG) were conducted to demonstrate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (ATF-PEG-IO-830) and were then imaged to further demonstrate the ability of this FMT endoscope for imaging small animals.

AB - We present a novel FMT endoscope by using a MEMS scanning mirror and an optical fiberscope. The diameter of this highly miniaturized FMT device is only 5 mm. To our knowledge, this is the smallest FMT device we found so far. Several phantom experiments based on indocyanine green (ICG) were conducted to demonstrate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (ATF-PEG-IO-830) and were then imaged to further demonstrate the ability of this FMT endoscope for imaging small animals.

KW - MEMS mirror

KW - endoscope

KW - fluorescence molecular tomography

KW - optical fiberscope

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DO - 10.1088/1361-6560/ab23b3

M3 - Article

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AN - SCOPUS:85068537743

SN - 0031-9155

VL - 64

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

IS - 12

M1 - 125015

ER -

Miniature fluorescence molecular tomography (FMT) endoscope based on a MEMS scanning mirror and an optical fiberscope

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Keywords

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